一般描述
Tumor necrosis factor-a converting enzyme (TACE; ADAM17) is a member of the ADAM (A Disintegrin And Metalloprotease) protein family implicated in cell-cell and cell-matrix interactions. TACE activates Notch signaling in the epidermal cells and has a critical function in the maintenance of barrier immunity. It is also involved in neurogenesis and muscle development.
应用
Tace Inhibitor Screening Assay Kit has been used in TACE (TNFa converting enzyme) activity assays.
特点和优势
Compatible with high-throughput handling systems.
适用性
适于筛选TACE抑制剂。
原理
The TACE Inhibitor Screening Assay Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of TACE inhibitors. TACE hydrolyzes a FRET-tagged substrate to release a fluorescent product (λex = 318/ λem = 449 nm), proportional to the enzymatic activity present.
仅试剂盒组分
产品编号
说明
- TACE Assay Buffer
- TACE Substrate
- TACE Enzyme
- Inhibitor Control, 0.1 mM GM6001
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 3
法规信息
新产品
Joseph Dosch et al.
Oncotarget, 8(39), 65090-65099 (2017-10-17)
ADAM17 (a disintegrin and metalloproteinase 17)/TACE (TNFα converting enzyme) has emerged as a potential therapeutic target in colorectal cancer (CRC) and other cancers, due in part to its role in regulating various tumor cell surface proteins and growth factors and
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