所有图片(1)
About This Item
经验公式（希尔记法）:
C10H8N2O2S
CAS号:
分子量:
220.25
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
red to orange
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
InChI
1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
InChI key
YBHQCJILTOVLHD-YVMONPNESA-N
基因信息
human ... MRE11A(4361)
应用
Mirin已被用作：
- 在辐照前的HCT116野生型细胞预处理中，用作减数分裂重组11（MRE11）的小分子抑制剂
- 作为感染猿猴病毒40的BSC-1细胞的Mre11抑制剂
- 在W12E细胞的预处理中，用于定量人乳头瘤病毒（HPV）附加体水平以及增强聚酰胺-25（PA-25）的作用
生化/生理作用
Mirin可导致细胞周期阻滞在G1期。 Mirin可增强病毒对抗病毒聚酰胺（AVP）的敏感性。在人乳头瘤病毒（HPV）附加体中，mirin通过形成双链DNA断裂来促进损伤作用。它有助于降低AVP的抑制浓度（IC50）。
Mirin是Mre11-Rad50-Nbs1复合物的抑制剂。它能够破坏Mre11的核酸酶活性，从而破坏DNA双链断裂修复能力。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability
Edwards TG, et al.
PLoS ONE, 8(10), e75406-e75406 (2013)
Thomas L Maurissen et al.
Nature communications, 11(1), 2876-2876 (2020-06-10)
Precise gene editing aims at generating single-nucleotide modifications to correct or model human disease. However, precision editing with nucleases such as CRIPSR-Cas9 has seen limited success due to poor efficiency and limited practicality. Here, we establish a fluorescent DNA repair
Atsushi Shibata et al.
Molecular cell, 53(1), 7-18 (2013-12-10)
MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design
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