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M9656

Sigma-Aldrich

H-8 dihydrochloride

>98% (HPLC)

别名:

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

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About This Item

经验公式（希尔记法）:
C12H15N3O2S · 2HCl
CAS号:
113276-94-1
分子量:
338.25
MDL编号:
MFCD00036962
UNSPSC代码:
12352200
PubChem化学物质编号:
24278039
NACRES:
NA.77

质量水平

100

方案

>98% (HPLC)

表单

powder

储存温度

2-8°C

SMILES字符串

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

基因信息

human ... CALCRL(10203) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Calcrl(25029)

生化/生理作用

cAMP and cGMP-dependent protein kinase inhibitor.

特点和优势

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000090222
0000074167
025M4746V
023M4715V
083H0691

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F Shirakawa et al.
Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)
We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by
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Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment
H Hidaka et al.
Biochemistry, 23(21), 5036-5041 (1984-10-09)
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

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