M9125
美沙吡啉 盐酸盐
别名:
N,N-Dimethyl-N′-(2-pyridinyl)-N′-(2-thienylmethyl)-1,2-ethanediamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C14H19N3S · HCl
化学文摘社编号:
分子量:
297.85
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
205-184-8
MDL number:
SMILES string
Cl.CN(C)CCN(Cc1cccs1)c2ccccn2
Gene Information
human ... HRH1(3269)
Biochem/physiol Actions
H1 histamine receptor antagonist. Potent liver carcinogen in rats.
Other Notes
Supplied only to established institutions. Telephone orders not accepted.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
H K Lee et al.
Mutation research, 341(2), 77-82 (1994-12-01)
The antihistaminic agent methapyrilene hydrochloride (MPH, CAS No. 135-23-9) has been reported as a potent rat hepatocarcinogen. However, neither the action mechanism nor mutagenicity of MPH have been clearly elucidated yet. Chromosomal aberration (CA) tests were performed with MPH in
G S Ratra et al.
Toxicological sciences : an official journal of the Society of Toxicology, 46(1), 185-196 (1999-02-03)
The mechanisms by which the antihistamine drug methapyrilene causes acute periportal hepatotoxicity in rats are not yet elucidated. This study investigated the effects of modulators of cytochrome P450 (CYP) activity on the hepatotoxicity of methapyrilene and also the effect of
S Noguchi et al.
Physiology & behavior, 51(6), 1123-1127 (1992-06-01)
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier
Michael Römer et al.
PloS one, 9(5), e97640-e97640 (2014-05-17)
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction
Yoko Nishimura et al.
Journal of applied toxicology : JAT, 35(2), 173-180 (2014-08-06)
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for
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