Anti-MLH1 (C-terminal) 兔抗

MLH1 is part of a large multi-subunit protein complex of tumor suppressors, DNA damage sensors, and signal transducers, named BRCA1-associated genome surveillance complex (BASC).

MutL homolog 1 (MLH1) is a nucleoprotein and a major component of mismatch repair system. The MLH1 gene is located in chromosome 3p21 and is made up of 19 exons. The protein has a molecular weight of 80kDa.

Anti-MLH1 (C-terminal) specifically recognizes human MLH1 (80-85 kDa).

synthetic peptide corresponding to amino acids 591-606 of human MLH1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding peptide sequence is conserved in human, rat, and mouse.

Anti-MLH1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation

A hereditary mutation in the MLH1 gene is implicated in nonpolyposis colorectal cancer-2.

MutL homolog 1 (MLH1) has been shown to be involved in promoting colorectal carcinogenesis.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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