所有图片(1)
About This Item
经验公式（希尔记法）:
C12H14N2O2
CAS号:
分子量:
218.25
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
推荐产品
产品名称
α-甲基- DL -色氨酸, crystalline
方案
≥98% (TLC)
质量水平
表单
crystalline
技术
tissue culture: suitable
颜色
light yellow
储存温度
2-8°C
SMILES字符串
CC(N)(Cc1c[nH]c2ccccc12)C(O)=O
InChI
1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)
InChI key
ZTTWHZHBPDYSQB-UHFFFAOYSA-N
应用
- 通过剥夺谷氨酰胺和级联血栓形成纳米工程声敏血小板协同增强声动力学肿瘤治疗: 该研究探索了使用α-甲基- DL -色氨酸，通过剥夺谷氨酰胺和诱发血栓形成来增进声动力学肿瘤治疗的效果，为癌症治疗提供了一条新途径（Zhou et al., 2023）。
- 靶向转运蛋白的加替沙星前药：合成、渗透性和眼睛局部给药: 该论文介绍了α-甲基- DL -色氨酸在靶向转运蛋白的前药开发中的应用， 改善了药物递送系统，特别是眼科治疗中的药物递送系统（Vooturi et al., 2012）。
- SLC6A14（ATB0,+）蛋白是一种高度集中的、具有广泛特异性的氨基酸转运蛋白，它是雌激素受体阳性乳腺癌治疗中有效的新型药物靶点。: 该研究考察了α-甲基- DL -色氨酸在雌激素受体阳性乳腺癌治疗中靶向 SLC6A14的作用，重点介绍了其成为治疗药的潜力（Karunakaran et al., 2011）。
生化/生理作用
α-甲基-DL-色氨酸是ATBo的阻滞剂，ATBo是一种氨基酸转运蛋白，其表达在癌症中上调。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Kazuya Kanemaru et al.
Neurochemistry international, 55(7), 529-535 (2009-05-26)
The neurotransmitter, serotonin, is involved in several brain functions, including both normal, physiological functions, and pathophysiological functions. Alterations in any of the normal parameters of serotonergic neurotransmission can produce several different psychiatric disorders, including major depression. In many instances, brain
Nela Pivac et al.
Neurochemistry international, 58(7), 826-832 (2011-03-19)
Lumped constant (LC) is a constant used to convert brain trapping constant of α-methyl-l-tryptophan (using α-(14)C-methyl-l-tryptophan) into the constant for conversion of tryptophan into serotonin (5-hydroxytryptamine, 5-HT), which can be then used with certain assumptions in the calculation of the
Hiroyuki Wakamoto et al.
Pediatric neurology, 39(3), 181-188 (2008-08-30)
Preliminary studies suggest that alpha[(11)C]methyl-l-tryptophan positron emission tomography can detect the epileptic focus within malformations of cortical development. We determined the sensitivity and specificity of alpha-[(11)C]methyl-l-tryptophan positron emission tomography in identifying epileptic focus in children with intractable, neocortical epilepsy with
Linda Booij et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(6), 419-423 (2012-01-20)
There is an increasing evidence that prenatal and early postnatal stressors have life long impacts on physical and mental health problems. Animal studies have shown that this could include enduring changes to brain serotonin neurotransmission. In the present study, we
Anita S D Saporta et al.
Journal of child neurology, 25(3), 336-342 (2009-09-15)
Previous studies in Tourette syndrome have reported lateralized abnormalities of neurotransmitters and microstructure of the cortico-striato-thalamo-cortical circuit. The authors analyzed the relationship between serotonin synthesis and microstructural changes in the subcortical structures (caudate nucleus, lentiform nucleus, and thalamus) related to
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