生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 75-80 kDa (doublet)
种属反应性
human
技术
immunoprecipitation (IP): 5-10 μg/mL using extracts of 293T cells
microarray: suitable
western blot: 0.5-1 μg/mL using nuclear extracts of MCF7 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MTA1(9112)
一般描述
MTA1 gene is mapped to human chromosome 14q32.33.
Metastasis associated 1 (MTA1) is a 80kDa protein which possesses four domains and several interaction motifs. It is made up of 715 amino acid residues.
特异性
Anti-MTA1 recognizes specifically MTA1.
免疫原
synthetic peptide corresponding to amino acids 626-641 of human MTA1, conjugated to KLH via an N-terminal added cysteine residue. The immunizing sequence is not present in other members of the family, MTA2 and MTA3.
应用
Anti-MTA1 antibody produced in rabbit has been used in:
- western blotting
- immunohistochemistry
- immunoprecipitation.
生化/生理作用
MTA1 interacts with cyclin-dependent kinase-activating kinase (CAK) is a component of the transcription factor II H (TFIIH) regulatory complex, suggesting its role as a signal transducer to mediate crosstalk between corepressor complexes and the general transcription machinery.
Metastasis associated 1 (MTA1) has been shown to be overexpressed in many types of cancers and has an important role in cancer malignancy. It takes part in the DNA repair process. As part of the nuclear remodeling and deacetylation complex (NuRD complex), it associates with deacetylated p53. MTA1 participates as a co-repressor and co-activator for many kinds of genes.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilu-tions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
De novo unbalanced translocation resulting in monosomy for distal 5p (5p14. 1? pter) and 14q (14q32. 31? qter) associated with fetal nuchal edema, microcephaly, intrauterine growth restriction, and single umbilical artery: prenatal diagnosis and molecular cytogenetic characterization
Chen CP, et al.
Taiwanese Journal of Obstetrics & Gynecology, 52(3), 401-406 (2013)
Christopher J Millard et al.
Cancer metastasis reviews, 33(4), 857-867 (2014-10-30)
Gene expression is controlled through the recruitment of large coregulator complexes to specific gene loci to regulate chromatin structure by modifying epigenetic marks on DNA and histones. Metastasis-associated protein 1 (MTA1) is an essential component of the nucleosome remodelling and
Involvement of metastasis tumor antigen 1 in hepatic regeneration and proliferation
Li W, et al.
Cellular Physiology and Biochemistry, 22(1-4), 315-326 (2008)
Ekjot Kaur et al.
Cancer metastasis reviews, 33(4), 1017-1024 (2014-11-07)
Metastasis-associated gene or metastasis tumor antigen 1 (MTA1) is a new member of cancer progression-related gene family. It was first identified in rat mammary adenocarcinoma and later recognized as an important constituent of nucleosomal remodeling complex (NuRD), displaying dual regulatory
MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions
Talukder AH, et al.
The Journal of Biological Chemistry, 278(13), 11676-11685 (2003)
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