M7033
NG-甲基-L-精氨酸 乙酸盐
≥98% (TLC), powder, nitric oxide synthase inhibitor
别名:
Nω-甲基-L-精氨酸 乙酸盐, L-NMMA, N5-（甲基脒基）-L-鸟氨酸 乙酸盐, NG-一甲基-L-精氨酸 乙酸盐
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关于此项目
经验公式（希尔记法）:
C7H16N4O2 · C2H4O2
化学文摘社编号:
分子量:
248.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
6674255
产品名称
NG-甲基-L-精氨酸 乙酸盐, ≥98% (TLC)
InChI key
IKPNWIGTWUZCKM-JEDNCBNOSA-N
SMILES string
CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
assay
≥98% (TLC)
form
powder
solubility
water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS3(4846)
mouse ... Nos2(18126)
rat ... Nos1(24598), Nos2(24599)
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Application
NG-甲基-L-乙酸精氨酸盐用于：
- 在受伤小鼠的伤口愈合研究中用作一氧化氮合酶（NOS）抑制剂
- 作为一氧化氮合酶（NOS）的抑制剂来研究小鼠干细胞的一氧化氮（NO）免疫抑制作用
- 作为抑制剂用于监测血细胞呼吸爆发测定中的NO水平
Biochem/physiol Actions
NG-甲基-L-精氨酸是神经元、内皮细胞和巨噬细胞中一氧化氮合酶的一种抑制剂。它可抑制内皮衍生的松弛因子并促进肺动脉和静脉的收缩。它能够立体选择性地抑制从精氨酸产生一氧化氮（NO）。它可促进肾上腺素和葡萄糖水平，从而导致中枢神经系统的高血糖症。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Safa Al Therwani et al.
BMC nephrology, 18(1), 86-86 (2017-03-16)
Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
Gold ME, et al.
Proceedings of the National Academy of Sciences of the USA, 87(12), 4430-4434 (1990)
Jonna Idh et al.
PloS one, 12(7), e0181221-e0181221 (2017-07-14)
Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical
Immune parameters in the common octopus (Octopus vulgaris Cuvier, 1797) naturally infected by the gastrointestinal protozoan parasite Aggregata octopiana
Castellanos-Martinez S and Gestal C
Aquaculture (Amsterdam, Netherlands), 497, 487-493 (2018)
NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase
Olken NM and Marletta MA
Biochemistry, 32(37), 9677-9685 (1993)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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