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方案
≥98% (TLC)
质量水平
表单
powder
颜色
white
mp
98-100 °C
应用
cell analysis
peptide synthesis
SMILES字符串
CC(S)C(=O)NCC(O)=O
InChI
1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
InChI key
YTGJWQPHMWSCST-UHFFFAOYSA-N
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应用
N-(2-巯丙酰)甘氨酸或Tiopronin已用于：
- 制备聚乙烯亚胺(PEI)包覆金微粒(PEI-gold)，进行核酸生物传递
- 研究活性氧(ROS)在异氟醚预处理诱导的体内神经保护中的再灌注期作用
- 作为ROS抑制剂，研究其对溶血磷脂酰胆碱(LPC)诱导的炎症小体激活的影响
生化/生理作用
N-(2-巯丙酰)甘氨酸(NMPG)是一种与自身免疫性低血糖相关的硫醇化合物。它是一种可扩散抗氧化剂，可降低结肠损伤的严重程度。NMPG还可减轻髓过氧化物酶活性，刺激缺氧诱导因子-1(HIF-1)-血管内皮生长因子(VEGF)溃疡愈合途径。
N-(2-巯基丙酰基)-甘氨酸是一种自由基清除剂。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Sang Hyun Lee et al.
Brain research, 1723, 146405-146405 (2019-08-28)
In this in vivo and in vitro study, we aimed to investigate whether isoflurane preconditioning-induced neuronal protection is mediated by reactive oxygen species (ROS) signaling at the reperfusion stage. In the in vivo study, Sprague-Dawley rats were subjected to middle
Pyritinol
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 2988-2989 (2006)
Wei Chen et al.
Journal of cardiovascular pharmacology, 73(5), 265-271 (2019-05-15)
Emulsified isoflurane (EI) has been shown to alleviate myocardial ischemia-reperfusion (IR) injury. However, previous reports have not been focused on the underlying mechanism. We used models of IR injury in Langendorff-isolated rat hearts to determine the relationship between the mechanism
Soohwan Yum et al.
Biochemical and biophysical research communications, 443(3), 1008-1013 (2013-12-24)
We investigated anti-colitic effects of N-(2-mercaptopropionyl)-glycine (NMPG), a diffusible antioxidant, in TNBS-induced rat colitis model and a potential molecular mechanism underlying the pharmacologic effect of the antioxidant. NMPG alleviated colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuated
Lei Cui et al.
Nanomedicine : nanotechnology, biology, and medicine, 9(2), 264-273 (2012-06-13)
The present study characterized the in vitro biological response of a comprehensive set of cancer cell lines to gold nanoparticles (2.7 nm) coated with tiopronin (AuNPs-TP). Our findings suggest that upon entering cells, the AuNPs-TP are sequestered in vacuoles such
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