M5883
7-Methylguanosine 5′-diphosphate sodium salt
≥92.5%, synthetic (organic), powder
别名:
7-Methyl-gdp, m7GDP
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关于此项目
经验公式（希尔记法）:
C11H17N5O11P2 · xNa+
化学文摘社编号:
分子量:
457.23 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥92.5%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
Storage temp.:
−20°C
产品名称
7-Methylguanosine 5′-diphosphate sodium salt, ≥92.5%
SMILES string
[Na+].[Na+].C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13
InChI
1S/C11H17N5O11P2.2Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
InChI key
VSMXIKIFPKDZJA-IDIVVRGQSA-L
biological source
synthetic (organic)
assay
≥92.5%
form
powder
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
storage temp.
−20°C
Quality Level
Application
7-Methylguanosine 5′-diphosphate sodium salt has been used as a component of the elution buffer for the purification of 5’capped RNA.
General description
7-Methylguanosine 5′-diphosphate (m7GDP) is derived when the human decapping Dcp2 enzyme cleaves the cap of the deadenylated mRNAs during the 5′–3′ mRNA decay pathway.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M Długosz et al.
Journal of biochemical and biophysical methods, 51(2), 179-193 (2002-06-14)
A method for extracting kinetic and optical parameters from progress curves for protein-ligand association, obtained by stopped-flow experiments, is described. The method is limited to one-step and two-step association kinetics, but it allows concentration of protein and offset of the
H Matsuo et al.
Nature structural biology, 4(9), 717-724 (1997-09-26)
eIF4E, the mRNA cap binding protein, is a master switch that controls eukaryotic translation. To be active, it must bind eIF4G and form the eIF4F complex, which also contains eIF4A. Translation is downregulated by association of eIF4E with 4E-BP, which
DcpS can act in the 5??3? mRNA decay pathway in addition to the 3??5? pathway
Erwin VD, et al.
Proceedings of the National Academy of Sciences, 100(21) (2003)
7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by Decapping Scavenger (DcpS) enzymes and potently inhibits their activity
Wypijewska A, et al.
Biochemistry, 51(40) (2012)
A B Sachs et al.
Nature structural biology, 7(5), 356-361 (2000-05-10)
The eukaryotic cap and poly(A) tail binding proteins, eIF4E and Pab1p, play important roles in the initiation of protein synthesis. The recent structures of the complex of eIF4E bound to the methylated guanosine (cap) found at the 5'end of messenger
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