所有图片(3)
About This Item
经验公式（希尔记法）:
C21H46NO4P
CAS号:
分子量:
407.57
MDL编号:
UNSPSC代码:
51191904
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
生物来源
synthetic (organic)
质量水平
描述
zwitterionic
方案
≥98% (perchloric acid titration)
表单
powder
溶解性
H2O: 10 mg/mL, clear, colorless
官能团
phospholipid
脂质类型
phospholipids
储存温度
room temp
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
InChI
1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
InChI key
PQLXHQMOHUQAKB-UHFFFAOYSA-N
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应用
- 作为一类新型抗利什曼原虫药物的多功能化吲哚吡咯杂化物的简易一锅法合成。: 这项研究强调了在患者对已知药物（如用作阳性对照参考品的米替福新）的耐药性日益增强的情况下，创新治疗的必要性，这可能为抗利什曼原虫药物的开发开辟新的方向（Ciccone et al., 2024）。
生化/生理作用
蛋白激酶C和磷脂酰胆碱合成抑制剂。用于内脏和皮肤利什曼病的治疗。对阴道毛滴虫甲硝唑耐药株和敏感株有效
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Thomas P C Dorlo et al.
Antimicrobial agents and chemotherapy, 52(8), 2855-2860 (2008-06-04)
The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and characterized the pharmacokinetics of miltefosine in a group of patients with Old World (Leishmania major) cutaneous leishmaniasis. Miltefosine plasma concentrations were determined in samples
Suresh K Tipparaju et al.
Journal of medicinal chemistry, 51(23), 7344-7347 (2008-11-08)
The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T. cruzi, and P. falciparum cultures followed by determination of IC(50) in L. donovani and
Nathan P Wiederhold et al.
Antimicrobial agents and chemotherapy, 57(2), 745-750 (2012-11-21)
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections. Our objective was to further evaluate the in vivo efficacy of miltefosine in
Maria V Papadopoulou et al.
Journal of medicinal chemistry, 54(23), 8214-8223 (2011-10-26)
A series of novel 2-nitro-1H-imidazole- and 3-nitro-1H-1,2,4-triazole-based aromatic and aliphatic amines were screened for antitrypanosomal activity and mammalian cytotoxicity by the Drugs for Neglected Diseases initiative (DNDi). Out of 42 compounds tested, 18 3-nitro-1,2,4-triazoles and one 2-nitroimidazole displayed significant growth
Abdullah Alotaibi et al.
Scientific reports, 9(1), 11364-11364 (2019-08-08)
Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana. The extracts were also tested against Crithidia fasciculata a close relative of Crithidia mellificae
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