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SMILES字符串
CC(N)(C(O)=O)c1ccc(cc1)C(O)=O
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
InChI key
DNCAZYRLRMTVSF-UHFFFAOYSA-N
基因信息
human ... GRM1(2911) , GRM2(2912) , GRM3(2913) , GRM5(2915)
rat ... Grm1(24414)
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生化/生理作用
Competitive antagonist at Group 1 (mGluR1 and mGluR5) and Group 2 (mGluR2 and mGluR3) metabotropic glutamate receptors.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
K M Huber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(1), 1-9 (1998-01-24)
The neurotransmitter glutamate, in addition to activating ligand-gated ion channels, also stimulates phosphoinositide (PI) hydrolysis in neurons by activating a group of G-protein-coupled metabotropic glutamate receptors (mGluRs). A role for mGluRs in synaptic plasticity originally was hypothesized based on the
Hilary Gerstein et al.
Neurobiology of learning and memory, 97(1), 17-29 (2011-09-29)
Homer1 belongs to a family of scaffolding proteins that interact with various post-synaptic density proteins including group I metabotropic glutamate receptors (mGluR1/5). Previous research in our laboratory implicates the Homer1c isoform in spatial learning. Homer1 knockout mice (H1-KO) display cognitive
Ana C Takakura et al.
Experimental physiology, 96(10), 989-999 (2011-07-12)
In the present study, we evaluated the role of glutamatergic mechanisms in the retrotrapezoid nucleus (RTN) in changes of splanchnic sympathetic nerve discharge (sSND) and phrenic nerve discharge (PND) elicited by central and peripheral chemoreceptor activation. Mean arterial pressure (MAP)
D D Schoepp et al.
Neuropharmacology, 36(1), 1-11 (1997-01-01)
The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes expressed in non-neuronal (RGT) cells is
Marta Navarrete et al.
Neuron, 68(1), 113-126 (2010-10-06)
Endocannabinoids and their receptor CB1 play key roles in brain function. Astrocytes express CB1Rs that are activated by endocannabinoids released by neurons. However, the consequences of the endocannabinoid-mediated neuron-astrocyte signaling on synaptic transmission are unknown. We show that endocannabinoids released
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