所有图片(1)
别名:
4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate
经验公式（希尔记法）:
C14H12N3NaO4S2 · xH2O
CAS号:
分子量:
373.38 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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检测方案
≥98% (HPLC)
形式
powder
颜色
light yellow to dark yellow
溶解性
DMSO: 5 mg/mL, clear
创始人
Boehringer Ingelheim
储存温度
room temp
SMILES字符串
O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O
InChI
1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1
InChI key
IZBZAOZGNNQKPJ-UHFFFAOYSA-M
基因信息
human ... PTGS2(5743)
应用
Meloxicam sodium salt hydrate has been used:
- as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
- as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
- as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
- to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells
生化/生理作用
Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.
特点和优势
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Anti-Inflammatory Effect of (7R, 8S)-Dehydrodiconiferyl Alcohol-9? Gamma-Methyl Ether from the Rhizome of Belamcanda Chinensis: Role of Mir-146a and Mir-155
Binh BT, et al.
Biomedicine and Pharmacotherapy, 9(3), 909-918 (2016)
Cyclooxygenase-2 enzyme inhibitors: place in therapy.
Noble SL, et al.
Am. Fam. Physician., 61(12), 3669-3676 (2000)
Safety of meloxicam to critically endangered Gyps vultures and other scavenging birds in India
Swarup DPRC, et al.
Animal Conservation, 10(2), 192-198 (2007)
Effect of the specific cyclooxygenase-2 inhibitor meloxicam on tumour growth and cachexia in a murine model
Hussey HJ and Tisdale MJ
International Journal of Molecular Medicine, 87(1), 95-100 (2000)
B Safieh-Garabedian et al.
Neuropharmacology, 39(9), 1653-1661 (2000-06-16)
We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of
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