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一般描述
Methoxypolyethylene glycol p-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative. PEGs are widely used as a covalent modifier of biologic macromolecules and particulates and for mechanism of drug delivery.
应用
Methoxypolyethylene glycol p-nitrophenyl carbonate has been used in a study to obtain unimolecular dendritic micelles designed as solubility enhancers. It has also been used in a study to investigate the properties of lipase from Candida rugosa modified with Mpeg. It is also useful for modification of proteins.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Properties of methoxy(polyethylene glycol)-lipase from Candida rugosa in organic solvents
Zacchigna, M., et al.
Il Farmaco Ed. Sc., 53, 758-758 (1998)
Hu Yang et al.
Journal of colloid and interface science, 273(1), 148-154 (2004-03-31)
Unimolecular dendritic micelles designed as solubility enhancers were obtained by coupling polyethylene glycol (PEG) to Starburst polyamidoamine (PAMAM) dendrimers. Micelles-750, -2000, and -5000 have a generation 3.0 dendrimer core (32 primary amine end groups) and PEG arms with molecular weights
F M Veronese et al.
Applied biochemistry and biotechnology, 11(2), 141-152 (1985-04-01)
A single-step method of activation of monomethoxypolyethylene glycols suitable for its binding to polypeptides and proteins is proposed. Based on the reaction with 2,4,5-trichlorophenylchloroformate or p-nitrophenylchloroformate, it gives reactive PEG-phenylcarbonate derivatives. The PEG intermediate is stable on storage, the activating
Chemistry of polyethylene glycol conjugates with biologically active molecules
Zalipsky, S., et al.
Advanced Drug Delivery Reviews, 16, 157-157 (1995)
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