生物来源
synthetic (organic)
质量水平
检测方案
≥99% (HPLC)
形式
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
InChI key
OLCWZBFDIYXLAA-IOSLPCCCSA-N
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应用
5′-(α,β-亚甲基)二磷酸腺苷可作为培养基组分,用于研究其对于CD73或调节胞外-5′-核苷酸酶介导的分化簇73(CD73)和腺苷能信号传导调控的抑制作用。
重悬
加热后可溶于水,最高约 50 mg/ml
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Angiogenesis, 7(3), 255-267 (2004-12-21)
The role of muscle contraction, prostanoids, nitric oxide and adenosine in the regulation of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell proliferative compounds in skeletal muscle cell cultures was examined. VEGF and bFGF mRNA
The Journal of pharmacology and experimental therapeutics, 302(3), 992-1001 (2002-08-17)
Previously, we have demonstrated that stimulation of the sympathetic nerves of the guinea pig vas deferens evokes release not only of the cotransmitters ATP and norepinephrine but also of soluble nucleotidases that break down extracellular ATP, ADP, and AMP into
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 58(2), 321-333 (2007-07-12)
ATP and adenosine are important extracellular regulators of glomerular functions. In this study, ATP release from glomeruli suspension and its extracellular metabolism were investigated. Basal extraglomerular ATP concentration (1nM) increased several fold during inhibition of ecto-ATPase activity, reflecting the basal
CD73 Regulates stemness and epithelial-mesenchymal transition in ovarian cancer-initiating cells
Stem Cell Reports, 10(4), 1412-1425 (2018)
TGFbeta-induced osteogenic potential of human amniotic fluid stem cells via CD73-generated adenosine production
Scientific Reports, 7(1) (2017)
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