生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
分子量
antigen 180 kDa
种属反应性
rat, human, mouse
技术
immunohistochemistry (frozen sections): 1:1,000
immunoprecipitation (IP): 3 μL using 200 μg of rat brain
western blot: 1 μg/mL using 35S-Protein A (with ECL dilutions may be higher)
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)
一般描述
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码N-甲基D-天冬氨酸r受体亚型2B (GluN2B) 它是N-甲基-D-天冬氨酸受体蛋白的重要组成部分。GRIN2B基因位于人染色体12p13.1。
免疫原
NR2B的C末端部分（984-1104位氨基酸）。
应用
在兔中生产的抗谷氨酸受体NMDAR2B（NR2B）抗体已被用于蛋白质印迹。
抗谷氨酸受体NMDAR2B（NR2B）抗体适用于免疫组织化学（1:1,000稀释，使用冰冻切片）、免疫沉淀（3μ L，使用200 μg大鼠大脑）和间接ELISA。该抗体也可用于蛋白质印迹（1μg / mL，使用（35S）-蛋白质A）和免疫印迹（180 kDa）。
生化/生理作用
功能性N-甲基-D-天冬氨酸（NMDA）受体复合物由NMDAR1（NR1）亚基和从NR2A到NR2D之中至少一个NMDAR2亚基组成。 这些受体复合物与耳蜗功能和神经元可塑性有关。NR2B受体的C末端可能调节突触定位。
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码在突触可塑性、语言习得、神经元图式形成（pattern formation）和短期记忆中起关键作用。GRIN2B基因突变会导致帕金森病、精神分裂症、双相障碍、阿尔茨海默症和强迫症。
外形
从碳酸氢铵（5 mM）冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Steve Standley et al.
PloS one, 7(6), e39585-e39585 (2012-07-05)
NMDA receptor NR2A/B subunits have PDZ-binding domains on their extreme C-termini that are known to interact with the PSD-95 family and other PDZ proteins. We explore the interactions between PSD-95 family proteins and the NR2A/B cytoplasmic tails, and the consequences
D Joelson et al.
Microscopy research and technique, 41(3), 246-262 (1998-05-30)
The distribution of immunoreactivity for the ionotropic N-methyl-D-aspartate (NMDA) receptor subunits was mapped in the cochlear nucleus of postnatal day (P) 7, P14, P21, and P28 gerbils. Frozen sections and serial plastic sections of tissue were incubated with antibodies to
R S Petralia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(10), 6102-6120 (1994-10-01)
Neuronal plasticity associated with learning, memory and development is controlled, in part, by NMDA receptors, which are complexes consisting of the subunit NMDAR1 (NR1) and one or more NMDAR2 subunits (NR2A-NR2D). We made a polyclonal antibody to a C-terminus peptide
Maowen Ba et al.
Behavioural brain research, 356, 41-45 (2018-08-22)
Augmented function of N-methyl-d-aspartate receptor subunit 2B (NR2B) and Src protein tyrosine kinase have been demonstrated to get involved in the pathological mechanisms of dyskinesia. In view of functional interactions between NR2B and Src, we investigated the effects of uncoupling
Mi Zhou et al.
Neuroscience, 376, 24-39 (2018-02-17)
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups.
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