M265
兔抗N-甲基D-天冬氨酸受体亚型2B多克隆抗体 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
产品名称
兔抗N-甲基D-天冬氨酸受体亚型2B多克隆抗体 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 180 kDa
species reactivity
rat, human, mouse
technique(s)
immunohistochemistry (frozen sections): 1:1,000
immunoprecipitation (IP): 3 μL using 200 μg of rat brain
western blot: 1 μg/mL using 35S-Protein A (with ECL dilutions may be higher)
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)
Biochem/physiol Actions
功能性N-甲基-D-天冬氨酸（NMDA）受体复合物由NMDAR1（NR1）亚基和从NR2A到NR2D之中至少一个NMDAR2亚基组成。 这些受体复合物与耳蜗功能和神经元可塑性有关。NR2B受体的C末端可能调节突触定位。
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码在突触可塑性、语言习得、神经元图式形成（pattern formation）和短期记忆中起关键作用。GRIN2B基因突变会导致帕金森病、精神分裂症、双相障碍、阿尔茨海默症和强迫症。
Application
在兔中生产的抗谷氨酸受体NMDAR2B（NR2B）抗体已被用于蛋白质印迹。
抗谷氨酸受体NMDAR2B（NR2B）抗体适用于免疫组织化学（1:1,000稀释，使用冰冻切片）、免疫沉淀（3μ L，使用200 μg大鼠大脑）和间接ELISA。该抗体也可用于蛋白质印迹（1μg / mL，使用（35S）-蛋白质A）和免疫印迹（180 kDa）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码N-甲基D-天冬氨酸r受体亚型2B (GluN2B) 它是N-甲基-D-天冬氨酸受体蛋白的重要组成部分。GRIN2B基因位于人染色体12p13.1。
Immunogen
NR2B的C末端部分（984-1104位氨基酸）。
Physical form
从碳酸氢铵（5 mM）冻干。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Naoya Morisada et al.
Human genome variation, 3, 16029-16029 (2016-09-23)
N-methyl D-aspartate receptor subtype 2B (GluN2B), encoded by GRIN2B, is one of the components of the N-methyl D-aspartate receptor protein. Aberrations in GRIN2B have been reported to be responsible for various types of neurodevelopmental disorders. We report a Japanese boy
HTR and GRIN2B Variant Associated with Cognition Dysfunction in Electric Workers.
Li Feng Wang et al.
Biomedical and environmental sciences : BES, 32(3), 220-225 (2019-04-17)
R S Petralia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(10), 6102-6120 (1994-10-01)
Neuronal plasticity associated with learning, memory and development is controlled, in part, by NMDA receptors, which are complexes consisting of the subunit NMDAR1 (NR1) and one or more NMDAR2 subunits (NR2A-NR2D). We made a polyclonal antibody to a C-terminus peptide
Mi Zhou et al.
Neuroscience, 376, 24-39 (2018-02-17)
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups.
Maowen Ba et al.
Behavioural brain research, 356, 41-45 (2018-08-22)
Augmented function of N-methyl-d-aspartate receptor subunit 2B (NR2B) and Src protein tyrosine kinase have been demonstrated to get involved in the pathological mechanisms of dyskinesia. In view of functional interactions between NR2B and Src, we investigated the effects of uncoupling
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