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M1555

MAHMA NONOate

Name: MAHMA NONOate
Brand: SIGMA

别名:

6-（2-羟基-1-甲基-2-亚硝基肼）-N-甲基-1-己胺, NOC-9

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关于此项目

经验公式（希尔记法）:

C₈H₂₀N₄O₂

化学文摘社编号:

146724-86-9

分子量:

204.27

NACRES:

NA.25

PubChem Substance ID:

24896668

UNSPSC Code:

12352106

MDL number:

MFCD01310509

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属性

Quality Level

200

shipped in

dry ice

storage temp.

−70°C

SMILES string

[H][N+]([H])(C)CCCCCCN(C)N([O-])N=O

InChI

1S/C8H19N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9H,3-8H2,1-2H3/q-1/p+1

InChI key

WASRCWNCCFPNEJ-UHFFFAOYSA-O

说明

Application

NO 供体

Biochem/physiol Actions

不发布： t _1/2 = 3 min（22°C 磷酸盐缓冲液）

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

NONOates regulate KCl cotransporter-1 and -3 mRNA expression in vascular smooth muscle cells.

Mauricio Di Fulvio et al.

American journal of physiology. Heart and circulatory physiology, 284(5), H1686-H1692 (2003-01-11)

Nitric oxide (NO) donors regulate KCl cotransport (KCC) activity and cotransporter-1 and -3 (KCC1 and KCC3) mRNA expression in sheep erythrocytes and in primary cultures of rat vascular smooth muscle cells (VSMCs), respectively. In this study, we used NONOates as

Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell death.

A M Vincent et al.

Journal of neurobiology, 40(2), 171-184 (1999-07-21)

Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH(i)) regulation during nitric oxide (NO)-induced toxicity. Neuronal

mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways.

Zhao Zhong Chong et al.

Current neurovascular research, 2(3), 197-211 (2005-09-27)

Metabotropic glutamate receptors (mGluRs) are expressed throughout the mammalian central nervous system and integrate a host of signal transduction pathways that determine cellular function, plasticity and injury. Yet, one of the more unique regulatory functions of this family of GTP-binding

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全球贸易项目编号

货号	GTIN
M1555-50MG	04061834040903