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L9664

氯雷他定

≥98% (HPLC), Histamine H1 receptor antagonist, powder

别名:

4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯, 氯雷他定

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关于此项目

经验公式（希尔记法）:
C22H23N2O2Cl
化学文摘社编号:
79794-75-5
分子量:
382.88
UNSPSC Code:
12352200
PubChem Substance ID:
24278525
NACRES:
NA.77
MDL number:
MFCD00672869
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200
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产品名称

氯雷他定, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: soluble 50 mg/mL, H2O: insoluble

originator

Schering Plough

storage temp.

2-8°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)
rat ... Hrh1(24448)

Biochem/physiol Actions

氯雷他定是一种非镇静性组胺H1受体拮抗剂。其可抑制双孔结构域钾通道K2P18.1（也称为TRESK或KCNK18）。
非镇静组胺H1-受体拮抗剂。

Features and Benefits

该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512665
0000512665
0000476689
0000476689
0000481310

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F M Baroody et al.
Allergy, 55 Suppl 64, 17-27 (2001-04-09)
The primary mechanism of antihistamine action in the treatment of allergic diseases is believed to be competitive antagonism of histamine binding to cellular receptors (specifically, the H1-receptors), which are present on nerve endings, smooth muscles, and glandular cells. This notion
Nemanja Kolašinac et al.
International journal of pharmaceutics, 436(1-2), 161-170 (2012-07-10)
The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of the poorly water soluble drug substance desloratadine that can be used for the preparation of immediate release tablet formulation. Two commercially available poloxamer
J Kornhuber et al.
Neuropharmacology, 34(7), 713-721 (1995-07-01)
Amantadine (1-amino-adamantane) is clinically used for the management of Parkinson's disease and drug-induced extrapyramidal symptoms. It has previously been shown that amantadine is a low-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with rapid blocking and unblocking channel kinetics (Ki-value at the
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全球贸易项目编号

货号GTIN
L9664-10MG04061833966860
L9664-50MG04061832082769