所有图片(1)
About This Item
经验公式（希尔记法）:
C13H26N2O3 · HBr
CAS号:
分子量:
339.27
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
推荐产品
产品名称
亮氨酸-亮氨酸甲酯 氢溴酸盐, ≥97% (TLC)
质量水平
方案
≥97% (TLC)
表单
powder
颜色
white
储存温度
−20°C
SMILES字符串
Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C
InChI
1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H
InChI key
QIPBCIHWFATZOF-UHFFFAOYSA-N
相关类别
应用
- VCP 可维持分化骨骼肌中的溶酶体稳态和TFEB活性。: 该论文讨论了肌肉细胞中溶酶体功能和转录因子活性的维持，肌肉细胞可能受到影响细胞过程的小分子制剂（如亮氨酸-亮氨酸甲酯 氢溴酸盐）的影响。 (Arhzaouy et al., 2019).
生化/生理作用
Leu-Leu甲酯（LLME，Leu-Leu-OMe）可用于诱导免疫细胞（如肥大细胞、吞噬细胞、单核细胞/巨噬细胞和自然杀伤细胞）的蛋白酶依赖性细胞死亡（细胞凋亡）。
对自然杀伤T细胞有毒性的肽。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A Poloni et al.
Leukemia, 20(2), 329-335 (2005-12-13)
The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell source was bone marrow (BM) in eight patients and G-CSF-mobilized peripheral blood hematopoietic cells in 18
F R Melo et al.
Scandinavian journal of immunology, 74(4), 354-362 (2011-06-08)
Mast cells (MC) have pathogenic roles in numerous disorders, and strategies that stabilize MC or induce MC apoptosis are therefore emerging as possible therapeutic regimens. A typical feature of MC is their high content of secretory lysosomes (granules), containing numerous
Thiele, D.L. and Lipsky, P.E.
Federation Proceedings, 44, 590-590 (1985)
Chrisovalantis Papadopoulos et al.
The EMBO journal, 36(2), 135-150 (2016-11-01)
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates
M Odaka et al.
Photochemistry and photobiology, 63(6), 800-806 (1996-06-01)
L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), an apoptosis inducer in natural killer cells and macrophages, was caged with trans-o-hydroxycinnamoyl (3a-d), trans-o-mercaptocinnamoyl (4) and o-nitrobenzyl derivatives (5a, b), and the photochemical reactivity of these derivatives in phosphate-buffered saline containing 1% dimethyl sulfoxide and
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