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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
secondary antibodies
克隆
HP-6054, monoclonal
包含
15 mM sodium azide
技术
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:1,000 using using 2 μg/ml of human IgG myeloma containing lambda light chains as the coating protein
radioimmunoassay: suitable
western blot: suitable
同位素/亚型
IgG2a
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
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相关类别
一般描述
Monoclonal Anti-Human Lambda Light Chains (mouse IgG2a isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins are composed of two heavy and two light polypeptide chains held together by noncovalent forces and usually by interchain disulfide bridges. The various types of human (and other mammalian) immunoglobulins contain one of the two existing light chain types, either κ or λ in which multiple structural differences are reflected in antigenic variety, mainly the N-terminal (variable) domain of the chains.
特异性
The antibody is specific for human lambda (λ) light chains. This antibody is reactive with intact IgG (λ), IgA (λ), free lambda light chains and Bence-Jones lambda light chains. It is non-reactive with kappa light chains.
免疫原
Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads.
应用
Monoclonal Anti-Human Lambda Light Chains (Bound and Free) antibody produced in mouse has been used:
- in immunohistochemistry
- in enzyme-linked immunosorbent assay (ELISA) assay
- in immunohistology
- in radioimmunoassay (RIA)
- in precipitation assays
- in immunoblotting
- as capture antibodies in quantitative ELISA
生化/生理作用
Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Primary lymphoma of the central nervous system: a clinical-pathological and immunohistochemical study of ten autopsy cases
Costa H, et al.
Arquivos de Neuro-Psiquiatria, 64(4), 976-982 (2006)
Maria Elena Villani et al.
Plant biotechnology journal, 7(1), 59-72 (2008-09-17)
The aims of this work were to obtain a human antibody against the tumour-associated antigen tenascin-C (TNC) and to compare the yield and quality of plant-produced antibody in either stable transgenics or using a transient expression system. To this end
A human immunoglobulin lambda locus is similarly well expressed in mice and humans
Popov AV, et al.
The Journal of Experimental Medicine, 189(10), 1611-1620 (1999)
Patrizia Circelli et al.
Bioengineered bugs, 1(3), 221-224 (2011-02-18)
We have recently described an efficient transient expression system mediated by Agrobacterium tumefaciens for the production of HIV-1 Nef protein in Nicotiana benthamiana plants. In order to enhance the yield of recombinant protein we assayed the effect of three gene-silencing
Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more
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