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安全信息

L6004

Sigma-Aldrich

林可霉素 盐酸盐

≥90% (TLC)

别名:

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside 盐酸盐, 林可霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C18H34N2O6S · HCl
CAS号:
859-18-7
分子量:
443.00
Beilstein:
4171650
EC 号:
212-726-7
MDL编号:
MFCD00083647
UNSPSC代码:
51284507
PubChem化学物质编号:
329817633
NACRES:
NA.85

质量水平

200

方案

≥90% (TLC)

效能

800-900 units per mg

颜色

white to faint yellow

溶解性

H2O: soluble 50 mg/mL

抗生素抗菌谱

Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI key

POUMFISTNHIPTI-BOMBIWCESA-N

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相关类别

一般描述

化学结构：大环内酯

应用

盐酸林可霉素是一种抗生素，用于研究蛋白质合成抑制、细菌抗生素耐药性以及蛋白质和表面活性剂的结合 它是由 链霉菌 var. Lincolnensis 产生。

生化/生理作用

作用方式：林可霉素可通过在23S rRNA的肽基转移酶环区域内形成交联来抑制细菌蛋白质的合成。†

抗菌谱：盐酸林可霉素对革兰氏阳性菌有效。

制备说明

该产品在水中的溶解度为50 mg/mL，产生澄清无色的溶液。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
112K0566
WXBF4028V
WXBF1860V
WXBF0162V
WXBD7899V

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Neelam Keswani et al.
Journal of biochemistry, 148(1), 71-84 (2010-04-02)
The thermodynamics of interaction of neomycin and lincomycin with bovine serum albumin (BSA) and human serum albumin (HSA) has been studied using isothermal titration calorimetry (ITC), in combination with UV-visible, steady state and time resolved fluorescence spectroscopic measurements. Neomycin is
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Charlotte M M Gommers et al.
Plant physiology, 185(1), 67-76 (2021-02-26)
When germinating in the light, Arabidopsis (Arabidopsis thaliana) seedlings undergo photomorphogenic development, characterized by short hypocotyls, greening, and expanded cotyledons. Stressed chloroplasts emit retrograde signals to the nucleus that induce developmental responses and repress photomorphogenesis. The nuclear targets of these
PanGyi Kim et al.
Chemosphere, 89(1), 10-18 (2012-05-09)
Chronic toxicity of acetaminophen and lincomycin were evaluated using freshwater organisms including two crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). H295R, a human adrenal cell was also used to understand the effects on steroidogenesis. In 21
P Calza et al.
Environmental science and pollution research international, 20(4), 2262-2270 (2012-08-02)
The aqueous environmental fate of two antibiotics, lincomycin and clarithromycin, and an antiepileptic drug, carbamazepine, was investigated by monitoring drugs decomposition and identifying intermediates in Po river water (North Italy). Initially, control experiments in the dark and under illumination were
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