推荐产品
生物来源
Escherichia coli (O55:B5)
质量水平
形式
aqueous solution
浓度
1 mg/mL
颜色
white to faint yellow
溶解性
water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
运输
wet ice
储存温度
2-8°C
正在寻找类似产品? 访问 产品对比指南
一般描述
本品为 0.2 μm 过滤水溶液，含 1 mg/mL 来自大肠杆菌血清型 O55:B5 的脂多糖 (LPS)。来源菌株为 CDC 1644-70。这种 LPS 血清型已被用于感染性休克和心肌炎的研究。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖位于膜的外层，在非包膜菌株中，暴露在细胞表面。它们有助于外膜的完整性，保护细胞免受胆盐和亲脂性抗生素的作用。
制备说明
用于制备溶液的 LPS 经过苯酚提取和凝胶过滤层析纯化。通过苯酚提取制备的脂多糖含有高达 60% 的 RNA 和少于 1% 的蛋白质。随后通过凝胶过滤色谱法进行纯化，可去除苯酚提取的 LPS 中存在的大部分蛋白质，但留下的产物仍含有 10-20% 的核酸。采用离子交换色谱法进一步纯化，得到含 < 1% 蛋白质和 < 1%RNA 的 LPS 产品。
相关产品
产品编号
说明
价格
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Qing Lu et al.
American journal of physiology. Lung cellular and molecular physiology, 301(6), L847-L857 (2011-10-11)
Cigarette smoke (CS) is a major cause of chronic lung and cardiovascular diseases. Recent studies indicate that tobacco use is also a risk factor for acute lung injury (ALI) associated with blunt trauma. Increased endothelial cell (EC) permeability is a
Eric Danilo Pauls Sotelo et al.
Veterinary sciences, 7(2) (2020-05-06)
Several studies in human and equine medicine have produced controversial results regarding the role of dimethylsulfoxide (DMSO) as a therapeutic agent. This study aimed to evaluate the effect of joint lavage with different DMSO concentrations on biomarkers of synovial fluid
Janny C de Grauw et al.
Arthritis research & therapy, 11(2), R35-R35 (2009-03-11)
Inflammation is an important feature of many joint diseases, and levels of cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little is known about the magnitude and time course of inflammation-induced changes in cartilage tissue
Lauren E Adams et al.
Antioxidants (Basel, Switzerland), 10(3) (2021-04-04)
Therapeutic hypothermia does not improve outcomes in neonatal hypoxia ischemia (HI) complicated by perinatal infection, due to well-described, pre-existing oxidative stress and neuroinflammation that shorten the therapeutic window. For effective neuroprotection post-injury, we must first define and then target CNS
Long-Xiang Su et al.
Chinese medical journal, 132(11), 1336-1343 (2019-03-19)
It has recently been recognized that serum vimentin is elevated in infectious diseases, and that vimentin plays a role in regulating neutrophils and macrophages associated inflammation. However, the mechanisms are unclear. This study was designed to explore the role of
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门