L4524
脂多糖 来源于大肠杆菌 055:B5
purified by ion-exchange chromatography, TLR ligand tested
别名:
LPS
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
biological source
Escherichia coli (O55:B5)
Quality Level
form
lyophilized powder
purified by
ion-exchange chromatography
impurities
<1% Protein, <1% RNA
color
white to yellow cast
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
本产品是从大肠杆菌血清型 O55：B5 中提取而来，并通过离子交换进行了纯化。源菌株是 CDC 1644-70。LPS O55：B5 已用于刺激人腹膜巨噬细胞，以 1 ng/mL 的浓度，并以 1-100 ng/mL 的浓度刺激马腹膜巨噬细胞。
Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包膜菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的影响。
Preparation Note
产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生模糊的淡黄色溶液。在涡旋，并升温至 70-80 oC 后，在含水盐水中得到更浓缩但仍然浑浊的溶液（20 mg/ml）。脂多糖是在每种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。有机溶剂不能提供更澄清的溶液。甲醇产生具有漂浮物的浑浊悬浮液，而水产生均匀浑浊溶液。
Still not finding the right product?
Explore all of our products under 脂多糖 来源于大肠杆菌 055:B5
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
Yoshitaka Shirasaki et al.
Scientific reports, 4, 4736-4736 (2014-04-23)
Protein secretion, a key intercellular event for transducing cellular signals, is thought to be strictly regulated. However, secretion dynamics at the single-cell level have not yet been clarified because intercellular heterogeneity results in an averaging response from the bulk cell
Arij Faksh et al.
Pediatric research, 79(3), 391-400 (2015-11-06)
Antenatal inflammation and preterm birth are associated with the development of airway diseases such as wheezing and asthma. Utilizing a newborn mouse model, we assessed the effects of maternal inflammation and postnatal hyperoxia on the neonatal airway. Pregnant C57/Bl6 dams
Laura B Fanning et al.
PloS one, 8(2), e57007-e57007 (2013-02-23)
Leukocyte Immunoglobulin-like Receptor B4 (LILRB4) null mice have an exacerbated T helper cell type 2 (Th2) immune response and pulmonary inflammation compared with Lilrb4(+/+) animals when sensitized intranasally with ovalbumin (OVA) and low-dose lipopolysaccharide (LPS) followed by challenge with OVA.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L4524-5MG | 04061833957592 |
| L4524-25MG | 04061833957585 |
| L4524-10MG | 04061833272473 |