推荐产品
生物来源
Escherichia coli (O55:B5)
质量水平
形式
lyophilized powder
纯化方式
phenol extraction
技术
cell based assay: suitable
杂质
<3% Protein (Lowry)
颜色
off-white to tan
溶解性
water: soluble
应用
cell analysis
clinical research
life science and biopharma
运输
ambient
储存温度
2-8°C
正在寻找类似产品? 访问 产品对比指南
一般描述
脂多糖 (LPS) 是糖脂，由连接单个或多个脂肪酸的碳水化合物单元组合而成，存在于革兰氏阴性菌细胞壁中。LPS是外膜的重要组成部分，结构由脂质A、葡萄糖胺基磷脂、短核寡糖和O-抗原（远端多糖）组成。
应用
来自大肠杆菌O55:B5的脂多糖已用于：
- 刺激肝细胞和非实质细胞
- 刺激脾脏并研究Malitaf基因在鱼钝头鲷中的表达
- 作为伴刀豆球蛋白A（ConA）和D-半乳糖胺/脂多糖（D-GalN/LPS）暴发性肝炎模型的一部分用于研究天然化合物橙皮素的作用
- 诱导少突胶质细胞毒性，以评估几种化合物的神经保护作用
- 诱导大鼠肌少症，以评估载姜黄素疏水表面改性羟基磷灰石的抗氧化作用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖 (LPS) 建立起保护性渗透屏障，阻止抗生素和胆汁盐进入，从而使革兰氏阴性菌具备天然耐药性。LPS影响细菌致病性，毕竟宿主免疫系统主要面对的是细菌LPS成分。LPS是一种内毒素兼高免疫原性抗原，可以增强免疫系统。LPS 的脂质 A 通过 Toll 样受体 4 (TLR4) 刺激宿主细胞。
其他说明
For additional information on our range of Biochemicals, please complete this form.
For optimal reconstitution of LPS products, an intensive vortex is required before use, regardless of the container type. Ensure that the storage solution concentration is at least 1 mg/ml. While borosilicate (silanized) containers are recommended, polypropylene (PP) plastic containers may also be used.
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Yun Feng et al.
Stem cell research & therapy, 11(1), 2-2 (2020-01-05)
ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-like peptide 1 (GLP-1) agonist, possesses anti-inflammatory and proliferation promotion functions
Ya-Jyun Liang et al.
Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown
Outer membrane permeability and antibiotic resistance
Delcour A H, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1794(5) , 808-816 (2009)
A liver microphysiological system of tumor cell dormancy and inflammatory
responsiveness is affected by scaffold properties
responsiveness is affected by scaffold properties
Clark AM
Cancer Discovery null
Promising neuroprotective effects of ?-caryophyllene against LPS-induced oligodendrocyte toxicity: A mechanistic study
Askari V R and Shafiee-Nick R
Biochemical Pharmacology, 159, 154-171 (2019)
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门