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主要文件

L2880

Sigma-Aldrich

脂多糖 来源于大肠杆菌 055:B5

purified by phenol extraction

别名:

LPS

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10 MG
CN¥650.36
25 MG
CN¥1,394.93
100 MG
CN¥2,699.25
500 MG
CN¥13,441.78

CN¥650.36

国内现货，预计发货时间April 17, 2025详情

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10 MG
CN¥650.36
25 MG
CN¥1,394.93
100 MG
CN¥2,699.25
500 MG
CN¥13,441.78

About This Item

CAS号:
93572-42-0
EC 号:
297-473-0
MDL编号:
MFCD00164401
UNSPSC代码:
12352201
NACRES:
NA.25

CN¥650.36

国内现货，预计发货时间April 17, 2025详情

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生物来源

Escherichia coli (O55:B5)

质量水平

300

表单

lyophilized powder

纯化方式

phenol extraction

技术

cell based assay: suitable

杂质

<3% Protein (Lowry)

颜色

off-white to tan

溶解性

water: soluble

应用

cell analysis
clinical research
life science and biopharma

运输

ambient

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L4524L2637L6529
Lipopolysaccharides from Escherichia coli O55:B5 purified by phenol extraction

L2880

Lipopolysaccharides from Escherichia coli O55:B5

Lipopolysaccharides from Escherichia coli O55:B5 purified by ion-exchange chromatography, TLR ligand tested

L4524

Lipopolysaccharides from Escherichia coli O55:B5

Lipopolysaccharides from Escherichia coli O55:B5 purified by gel-filtration chromatography

L2637

Lipopolysaccharides from Escherichia coli O55:B5

Lipopolysaccharides from Escherichia coli O55:B5 &#947;-irradiated, BioXtra, suitable for cell culture

L6529

Lipopolysaccharides from Escherichia coli O55:B5

biological source

Escherichia coli (O55:B5)

biological source

Escherichia coli (O55:B5)

biological source

Escherichia coli (O55:B5)

biological source

Escherichia coli (O55:B5)

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

300

solubility

water: soluble

solubility

water: soluble

solubility

water: soluble

solubility

H2O: 5 mg/mL, faintly hazy to hazy

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

一般描述

脂多糖 (LPS) 是糖脂，[1]由连接单个或多个脂肪酸的碳水化合物单元组合而成，存在于革兰氏阴性菌细胞壁中。[2]LPS是外膜的重要组成部分，结构由脂质A、葡萄糖胺基磷脂、短核寡糖和O-抗原（远端多糖）组成。[3]

应用

来自大肠杆菌O55:B5的脂多糖已用于：[4]
  • 刺激肝细胞和非实质细胞[5]
  • 刺激脾脏并研究Malitaf基因在鱼钝头鲷中的表达[6]
  • 作为伴刀豆球蛋白A（ConA）和D-半乳糖胺/脂多糖（D-GalN/LPS）暴发性肝炎模型的一部分用于研究天然化合物橙皮素的作用[7]
  • 诱导少突胶质细胞毒性，以评估几种化合物的神经保护作用[8]
  • 诱导大鼠肌少症，以评估载姜黄素疏水表面改性羟基磷灰石的抗氧化作用[9]
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。

生化/生理作用

脂多糖 (LPS) 建立起保护性渗透屏障，阻止抗生素和胆汁盐进入，从而使革兰氏阴性菌具备天然耐药性。LPS影响细菌致病性，毕竟宿主免疫系统主要面对的是细菌LPS成分。LPS是一种内毒素兼高免疫原性抗原，可以增强免疫系统。LPS 的脂质 A 通过 Toll 样受体 4 (TLR4) 刺激宿主细胞。[1]

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)
为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。
无论采用什么容器，本品(LPS)都要经过剧烈的涡旋振荡才能达到最佳的复溶效果，以备使用。储存液浓度至少为1 mg/ml。推荐使用硼硅酸（硅烷化）容器，也可使用聚丙烯(PP)塑料容器。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000428248
    0000428248
    0000428249
    0000428249
    0000428255

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    Yun Feng et al.
    Stem cell research & therapy, 11(1), 2-2 (2020-01-05)
    ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-like peptide 1 (GLP-1) agonist, possesses anti-inflammatory and proliferation promotion functions
    Ya-Jyun Liang et al.
    Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
    Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown
    Identification and Characterization of Lipopolysaccharide Induced TNFa Factor from Blunt Snout Bream, Megalobrama amblycephala
    Yina LV
    International Journal of Molecular Sciences, 18(2), 233-233 (2017)
    Glycolipid biosurfactants: Biosynthesis and related potential applications in food industry
    Ashby R D, et al.
    Journal of Separation Science, 307-334 (2023)
    The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
    Xueting Bai
    British Journal of Pharmacology, 174 (2017)
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