生物来源
soybean
质量水平
描述
zwitterionic
检测方案
≥99%
形式
lyophilized powder
官能团
phospholipid
脂质类型
phosphoglycerides
运输
ambient
储存温度
−20°C
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生化/生理作用
溶血卵磷脂为氧化型低密度脂蛋白的主要成分，并且与多种炎症反应包括动脉粥样硬化有关。用于使脊髓神经元脱髓鞘以及研究作为髓鞘再生基础的过程。它可激活蛋白激酶 C、p38 MAP 激酶、p42 MAP 激酶和 jun 激酶 (JNK) 途径，以及激活 c-jun 的转录。溶血卵磷脂在心肌缺血过程中积累并可能通过对细胞间隙连接通讯的解偶联诱发心率失常，以及通过提高心肌细胞的 Na+ 负荷增加缺血性损伤。它还可激活 TREK1、TREK2 和 TRAAK K+ 通道。
包装
在氩气下包装。
制备说明
通过磷脂酶 A 作用于大豆 L-α-磷脂酰胆碱 (P 6263) 制得。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Guillaume Bach et al.
Clinical and vaccine immunology : CVI, 17(3), 429-438 (2010-01-15)
Improving vaccine immunogenicity by developing new adjuvant formulations has long been a goal of vaccinologists. It has previously been shown that a natural mix of lysophosphatidylcholine (LPC) from chicken eggs promotes mature dendritic cell (DC) generation in vitro and primes
E de Lamirande et al.
Journal of andrology, 33(5), 1025-1035 (2012-03-10)
Capacitation (CAP) and acrosome reaction (AR) are sequential processes of sperm activation. Beside the known ionic, membrane, and transduction events and final release of proteolytic enzymes that help sperm movement toward the egg, chromatin changes, such as a physiological remodeling
Hui-Ching Tseng et al.
Cellular and molecular life sciences : CMLS, 75(24), 4599-4617 (2018-09-20)
Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Here, we demonstrated that LysoPC-induced COX-2 and IL-6 expression was inhibited by silencing NADPH oxidase 1, 2, 4
Oliver Murch et al.
British journal of pharmacology, 148(6), 769-777 (2006-06-06)
1. Lysophosphatidylcholine (LPC) modulates the inflammatory response and reduces mortality in animal models of sepsis. Here, we investigate the effects of LPC from synthetic (sLPC) and natural, soy bean derived LPC, (nLPC) sources on the organ injury/dysfunction caused by systemic
Hui-Ching Tseng et al.
Journal of lipid research, 60(9), 1573-1589 (2019-08-01)
Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation. Here, we evaluated the mechanisms underlying LPC-mediated collagen induction via mitochondrial events in human cardiac fibroblasts (HCFs), coupling application of
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