L0879
Leu-Leu-Leu
≥90% (elemental analysis), suitable for mass spectrometry (MS)
别名:
Trileucine
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关于此项目
经验公式（希尔记法）:
C18H35N3O4
化学文摘社编号:
分子量:
357.49
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
Leu-Leu-Leu, ≥90% (elemental analysis)
SMILES string
CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O
InChI
1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)
InChI key
DNDWZFHLZVYOGF-UHFFFAOYSA-N
assay
≥90% (elemental analysis)
form
powder
technique(s)
electron microscopy: suitable, mass spectrometry (MS): suitable
color
white
storage temp.
−20°C
Quality Level
Application
Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
此项目有
Anna Andrzejewska et al.
Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)
The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of
Hui Ding et al.
Biomaterials, 34(1), 217-225 (2012-10-16)
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as
Hui Ding et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)
Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into
Nicholas B Carrigy et al.
Annals of biomedical engineering, 48(4), 1169-1180 (2019-12-18)
Spray drying biologics into a powder can increase thermal stability and shelf-life relative to liquid formulations, potentially eliminating the need for cold chain infrastructure for distribution in developing countries. In this study, process modelling, microparticle engineering, and a supplemented phase
David Lechuga-Ballesteros et al.
Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge
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