L0664
洛索洛芬
solid
别名:
α-甲基-4-[(2-氧代环戊基)甲基]苯乙酸, 索洛芬
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H18O3
化学文摘社编号:
分子量:
246.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)
SMILES string
CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1
InChI key
YMBXTVYHTMGZDW-UHFFFAOYSA-N
form
solid
originator
Daiichi-Sankyo
Quality Level
Gene Information
human ... PTGS1(5742), PTGS2(5743)
Application
抗炎；止痛药
Features and Benefits
该化合物由 Daiichi-Sankyo 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Shintaro Suemasu et al.
Biochemical pharmacology, 84(11), 1470-1481 (2012-10-02)
We previously proposed that direct cytotoxicity of NSAIDs due to their membrane permeabilization activity, together with their ability to decrease gastric prostaglandin E(2), contributes to production of gastric lesions. Compared to loxoprofen (LOX), fluoro-loxoprofen (F-LOX) has much lower membrane permeabilization
S Kawai
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 47 Suppl 2, S102-S106 (1998-11-27)
Severe gastro-intestinal complications are a major cause of NSAID-induced deaths in cases of rheumatoid arthritis. We measured COX selectivity by using an intact cell assay system, and found that NS-398 is a highly COX-2-selective inhibitor. Meloxicam, etodolac and diclofenac also
Naoki Yamakawa et al.
Biological & pharmaceutical bulletin, 33(3), 398-403 (2010-03-02)
Pro-drugs of non-steroidal anti-inflammatory drugs (NSAIDs), such as loxoprofen are widely used for clinical purposes because they are not so harmful to the gastrointestinal mucosa. We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to
Youngbae Kim et al.
Archives of pharmacal research, 41(4), 459-466 (2018-03-25)
Loxoprofen is a non-steroidal anti-inflammatory drug of the 2-arylpropionic acid type, which has used to treat musculoskeletal disorders in the horse racing industry. However, it has also used illicitly to mask clinical signs of inflammation and pain in racehorses. Thus
Naoki Yamakawa et al.
Bioorganic & medicinal chemistry, 19(11), 3299-3311 (2011-05-17)
Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX activity at the gastrointestinal mucosa and in tissues with inflammation, respectively. We
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