Agency
USP/NF
meets USP testing specifications
质量水平
形式
solid
分子量
8.400 g/mol
pH值（酸碱度）
5.0-7.5(2.5% solution)
应用
sample preservation
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
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一般描述
Poloxamer 188是一种非离子型两亲共聚物，其中心链为疏水聚氧丙烯，末端为亲水聚氧乙烯。
应用
Poloxamer 188已用作细胞解离/最小基本介质（MEM）的组分，以使用 EpCAM 抗体偶联磁珠分选肿瘤细胞。
Poloxamer 188已被用作F17培养基中的补充剂，用于培养HEK293-6E细胞。它还被用作流式细胞分析(FACS)缓冲液的组分，用作保护细胞免受流体动力损害的非离子型除垢剂。
生化/生理作用
Poloxamer 188具有细胞保护、血液流变学、抗炎、抗血栓活性。它可以维持膜屏障功能的稳定。P188 可降低表面张力和疏水细胞粘附。它还能抑制受 Fe2+ 和 H2O2 刺激的脂质过氧化。
法律信息
WGK
WGK 1
S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Denise Chroscinski
eLife (2015)
Antibody humanization by molecular dynamics simulations?in-silico guided selection of critical backmutations
Christian Margretter
Journal of Molecular Recognition (2016)
Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
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