K3888
Kenpaullone
≥98%
别名:
9-溴-7,12-二氢-吲哚并[3,2-d][1]苯并吖庚因-6（5H）-酮, NSC 664704
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关于此项目
经验公式（希尔记法）:
C16H11BrN2O
化学文摘社编号:
分子量:
327.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Kenpaullone, ≥98%
InChI key
QQUXFYAWXPMDOE-UHFFFAOYSA-N
SMILES string
Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
assay
≥98%
form
solid
color
yellow
solubility
DMSO: 18 mg/mL, clear, yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... CDC2(983)
mouse ... Gsk3b(56637)
rat ... Gsk3b(84027)
相关类别
Application
Kenpaullone已被用作：
- 糖原合成酶激酶 3 (GSK3)/周期蛋白依赖性激酶(CDK)抑制剂，以研究对人类神经祖细胞系的影响
- Krupple类因子4 (KLF4)抑制剂，用于Gs-coupled designer GPCR (Gs DREADD= GsD)刺鼠相关肽(GsD-AgRP)小鼠
- GSK3/CDK抑制剂，以研究对海胆胚胎发育的影响。
Biochem/physiol Actions
Kenpaullone也是一种糖原合成酶激酶3β (GSK3β)的抑制剂。它还可抑制周期蛋白依赖性激酶1 (CDK1/cyclin B)、CDK2/cyclin A、CDK2/cyclin E和 CDK5/p25，主要通过三磷酸腺苷(ATP)结合的竞争性抑制。
Packaging
在氩气环境中储存
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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