推荐产品
方案
≥98% (HPLC)
≥98% (TLC)
表单
powder
溶解性
acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
储存温度
2-8°C
SMILES字符串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23
InChI
1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
InChI key
CAGLGYNQQSIUGX-SDBHATRESA-N
基因信息
rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)
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一般描述
Kinetin riboside is a ribosylated form of kinetin. It is a natural cytokinin plant hormone.
应用
Kinetin riboside may be used:
- to study its cytotoxic effects on plant and animal tumor cells
- to investigate its apoptotic effects in both cancer and immortalized cells
- to elucidate its influence on human prostate cell epithelial-mesenchymal transition in vitro
生化/生理作用
Kinetin riboside exhibits cytotoxic and antiproliferative activities. In addition, it also shows anticancer activity by inducing apoptosis in various types of cancers including myeloid leukemia cells, mouse melanoma B16F-10 cells, and plant tumor cells.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Yuki Ishii et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 13(1), 19-26 (2002-01-22)
We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin, isopentenyladenine, and
Dennison Trinh et al.
Journal of neurochemistry, 156(6), 715-752 (2021-02-23)
Mitochondria are essential for neuronal function. They produce ATP to meet energy demands, regulate homeostasis of ion levels such as calcium and regulate reactive oxygen species that cause oxidative cellular stress. Mitochondria have also been shown to regulate protein synthesis
Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines.
Dudzik P, Dulinska-Litewka J, Wyszko E, et al.
The Journal of Cell Biology, 112, 2115-2124 (2011)
Bernard Griffaut et al.
International journal of biological macromolecules, 34(4), 271-275 (2004-09-18)
The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for
Michael Webb et al.
Bioorganic & medicinal chemistry letters, 29(11), 1270-1277 (2019-04-08)
Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression regulators such as PPAR or AMPK, (2) using antioxidant compounds
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