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Merck
CN
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文件

K1751

Sigma-Aldrich

酮洛芬

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

别名:

2-(3-苯甲酰苯基)丙酸

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About This Item

经验公式（希尔记法）:
C16H14O3
CAS号:
22071-15-4
分子量:
254.28
EC 号:
244-759-8
MDL编号:
MFCD00055790
UNSPSC代码:
12352200
PubChem化学物质编号:
57654315
NACRES:
NA.77

product name

酮洛芬, ≥98% (TLC)

生物来源

synthetic

质量水平

200

检测方案

≥98% (TLC)

形式

powder

溶解性

ethanol: 50 mg/mL, clear, colorless to yellow

创始人

Bayer

SMILES字符串

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

基因信息

human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

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相关类别

一般描述

酮洛芬属于2-芳基丙酸类化合物。

应用

酮洛芬已被用于：
  • 作为检测样品，通过色谱和显微技术分析长储存期的影响
  • 作为非选择性COX抑制剂，在大鼠皮下注射，研究其对应激/盐酸甲基苯丙胺诱导的闭合蛋白、紧密连接蛋白-5和COX-2蛋白免疫反应性、β-营养不良聚糖的截短、脑水含量、以及异硫氰酸荧光素-葡聚糖外渗的变化的影响
  • 在磷酸盐缓冲液中研究其抑制热诱导白蛋白变性的能力

生化/生理作用

它可作为治疗强直性脊柱炎、类风湿性关节炎和骨关节炎的有效药物。 它还具有解热和镇痛作用。酮洛芬可防止前列腺素合成酶的作用。
非甾体类抗炎化合物，具有COX-1选择性。

特点和优势

该化合物由Bayer开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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In vitro chiral conversion, phase separation, and wave propagation in aged profen solutions
Sajewicz M, et al.
Journal of Liquid Chromatography and Related Technologies, 32(9), 1359-1372 (2009)
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Biomolecules, 11(6) (2021-07-03)
The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals. Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
Yiyun C, et al.
European Journal of Medicinal Chemistry, 40(12), 1390-1393 (2005)
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International journal of molecular sciences, 22(18) (2021-09-29)
The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3
Nicole A Northrop et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7(4), 951-968 (2012-07-27)
Studies of methamphetamine (Meth)-induced neurotoxicity have traditionally focused on monoaminergic terminal damage while more recent studies have found that stress exacerbates these damaging effects of Meth. Similarities that exist between the mechanisms that cause monoaminergic terminal damage in response to
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Chromatograms

application for HPLCapplication for HPLCapplication for HPLC

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