所有图片(1)
About This Item
经验公式（希尔记法）:
C14H16N3OCl
CAS号:
分子量:
277.75
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
H2O: insoluble
创始人
Johnson & Johnson
储存温度
room temp
SMILES字符串
CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
InChI
1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChI key
HUQJRYMLJBBEDO-UHFFFAOYSA-N
应用
JNJ7777120 has been used as a histamine-4 receptor antagonist:
- to study its effects on the pro-inflammatory microglia in rats
- to study its effects on the Parkinson′s-like pathology in rat brain
- to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
生化/生理作用
JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qiuyuan Fang et al.
Brain, behavior, and immunity, 92, 127-138 (2020-11-30)
Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers and enhanced histamine levels have been observed in the substantia nigra of PD-postmortem brains. Histamine-induced
Susanne Mommert et al.
International archives of allergy and immunology, 166(3), 225-230 (2015-05-01)
Natural killer (NK) cells have been detected in the lesional skin of patients with inflammatory skin diseases, where high levels of histamine are also present. Therefore, we investigated the effect of histamine, in particular via the histamine H4 receptor (H4R)
Ilaria Dettori et al.
Frontiers in pharmacology, 9, 1231-1231 (2018-11-14)
Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by excitoxicity, is followed by a secondary brain injury that develops from hours to days after ischemia. Extracellular levels of histamine increase in
C Hoffmann et al.
Molecular pharmacology, 88(3), 552-560 (2015-07-15)
Over the past decade the kinetics of ligand binding to a receptor have received increasing interest. The concept of drug-target residence time is becoming an invaluable parameter for drug optimization. It holds great promise for drug development, and its optimization
Heiko Schenk et al.
Immunopharmacology and immunotoxicology, 38(5), 379-384 (2016-08-26)
The modulation of antigen uptake and activation of dendritic cells (DCs) by histamine may function as a regulator of inflammation. Therefore, we sought to determine the impact of histamine on antigen uptake by and activation of murine DCs. DCs from
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