产品名称
Anti-Human IgM (μ-chain specific) antibody produced in rabbit, whole antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
secondary antibodies
clone
polyclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:20,000
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
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Application
Anti-Human IgM (μ-chain specific) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.
Biochem/physiol Actions
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
IgM serves as prime antibody in providing defense. It activates complement C1q. It is regarded as a marker for identifying tumor-associated antigens. Hyper-IgM syndrome is implicated with high IgM levels accompanied by low IgA, IgG and IgE levels.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
IgM is a pentameric immunoglobulin, with each monomer having a light and heavy chain. The two types of IgM comprise natural and adaptive.
Preparation Note
treated to remove lipoproteins
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
常规特殊物品
此项目有
Evaluation of a patient with hyper-IgM syndrome
Uygungil B, et al.
The Journal of Allergy and Clinical Immunology, 129(6), 1692-1692 (2012)
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias
Czajkowsky DM and Shao Z
Proceedings of the National Academy of Sciences of the USA, 106(35), 14960-14965 (2009)
Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer
Diaz-Zaragoza M, et al.
Oncology Reports, 34(3), 1106-1114 (2015)
Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment
Haroun M and El-Masry MH
Central European Journal of Immunology, 33, 208-212 (2008)
E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we
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Instructions
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