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Merck
CN

I7634

Sigma-Aldrich

D-异亮氨酸

≥98% (TLC)

别名:

(2R, 3R)-2-氨基-3-甲基戊酸

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About This Item

线性分子式:
C2H5CH(CH3)CH(NH2)CO2H
CAS号:
分子量:
131.17
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

产品名称

D-异亮氨酸, ≥98% (TLC)

质量水平

方案

≥98% (TLC)

表单

powder

杂质

≤10% allo-isomer

颜色

white

应用

cell analysis

SMILES字符串

CC[C@@H](C)[C@@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m1/s1

InChI key

AGPKZVBTJJNPAG-RFZPGFLSSA-N

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应用


  • 利用灵敏的手性氯标记探针,通过HPLC-MS/MS对尿液中含手性胺的胃癌生物标记物进行代谢轮廓分析。:Huang等人(2021)的这项研究探索了将d -异亮氨酸作为胃癌的生物标志物,利用HPLC-MS/MS的先进代谢分析技术检测尿液样本中的手性含氨基化合物(Huang et al., 2021)。

  • 异霉素N合成酶通过两个硫原子结合δ-(L-α-氨基己二酰)-L-半胱氨酸-D-硫代异亮氨酸。:Clifton等人(2011)描述了异霉素N合成酶与一种含有d -异亮氨酸的化合物的结合机制,强调了异霉素N合成酶在抗生素生物合成和酶相互作用研究中的作用(Clifton et al., 2011)。

  • 抗生素长卡霉素的总结构。:Shiba和Mukunoki(1975)确定了以D-异色氨酸为关键成分的抗生素长春新碱的完整结构,有助于了解其抗菌特性(Shiba and Mukunoki, 1975)。

生化/生理作用

D-异亮氨酸可用于帮助对各种D-氨基酸氧化酶进行表征和区分。在B16F0黑色素瘤细胞中诱导色素沉着等过程中,D-异亮氨酸可用于区分D-和L-异亮氨酸的活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A Gholizadeh et al.
Biochemistry. Biokhimiia, 74(2), 137-144 (2009-03-10)
D-Amino acid oxidase (DAAO) is an FAD-dependent enzyme that metabolizes D-amino acids in microbes and animals. However, such ability has not been identified in plants so far. We predicted a complete DAAO coding sequence consisting of 1158 bp and encoding
Masago Ishikawa et al.
Biological & pharmaceutical bulletin, 30(4), 677-681 (2007-04-06)
Amino acids, the building blocks of proteins, play significant roles in numerous physiological events in mammals. As the effects of amino acids on melanogenesis have yet to be demonstrated, the present study was conducted to identify whether amino acids, in
Molecular aggregation in selected crystalline 1:1 complexes of hydrophobic D- and L-amino acids. IV. The L-phenylalanine series.
Gorbitz CH, Rissanen K, Valkonen A, Husab? A.
Acta Crystallographica Section C, Crystal Structure Communications, 65, 267-272 (2009)
Shouji Takahashi et al.
Journal of biochemistry, 159(3), 371-378 (2015-11-01)
D-Aspartate oxidase (DDO) catalyzes the oxidative deamination of acidic D-amino acids, whereas neutral and basic D-amino acids are substrates of D-amino acid oxidase (DAO). DDO of the yeast Cryptococcus humicola (ChDDO) has much higher substrate specificity to D-aspartate, but the
Ivan Kashkan et al.
Plants (Basel, Switzerland), 9(7) (2020-07-12)
Rapid progress in plant molecular biology in recent years has uncovered the main players in hormonal pathways and characterized transcriptomic networks associated with hormonal response. However, the role of RNA processing, in particular alternative splicing (AS), remains largely unexplored. Here

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