Monoclonal Anti-Interleukin-10 Receptor α antibody produced in mouse

Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10R is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10R mediated signalling is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.

The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.

purified recombinant human IL-10 soluble receptor α expressed in insect Sf 21 cells.

Anti-interleukin-10 receptor α antibody is suitable for neutralization reactions (ND50 is 0.03-0.1 μg/ml).

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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