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安全信息

I2765

Sigma-Aldrich

鹅膏氨酸

~95% (TLC), solid, neurotoxin

别名:

α-氨基-3-羟基-5-异噁唑乙酸

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About This Item

经验公式（希尔记法）:
C5H6N2O4
CAS号:
2552-55-8
分子量:
158.11
MDL编号:
MFCD00069294
UNSPSC代码:
12352209
PubChem化学物质编号:
24277994
NACRES:
NA.32

产品名称

鹅膏氨酸, ~95%, solid

方案

~95%

表单

solid

颜色

white

溶解性

H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL

SMILES字符串

NC(C(O)=O)C1=CC(=O)NO1

InChI

1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

InChI key

IRJCBFDCFXCWGO-UHFFFAOYSA-N

基因信息

rat ... Grm1(24414) , Grm2(24415)

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Rosetta(DE3)pLacI Competent Cells - Novagen

Rosetta Competent Cells - Novagen Rosetta host strains are BL21 derivatives designed to enhance the expression of eukaryotic proteins that contain codons rarely used in E. coli.

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Rosetta Competent Cells - Novagen

RosettaBlue Competent Cells - Novagen RosettaBlue host strains are NovaBlue derivatives that combine high transformation efficiency and with enhanced expression of eukaryotic proteins that contain codons rarely used in E. coli.

71058

RosettaBlue Competent Cells - Novagen

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

应用

鹅膏蕈氨酸作为神经毒素用于大鼠[1]。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。[2]
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术，以研究逆转增强剂诱导的发声变化。[3]

生化/生理作用

对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。
鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体，破坏丘脑网状核（NRT）。[4]它能诱导大量钙离子流入，导致神经元损伤。由于其具有兴奋性毒性功能，鹅膏蕈氨酸用于诱导产生神经退行性变。[5]

注意

吸湿

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000427329
    0000397349
    0000397350
    0000397350
    0000397349

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    Anja T Zai et al.
    Nature communications, 11(1), 5940-5940 (2020-11-25)
    Sensory substitution is a promising therapeutic approach for replacing a missing or diseased sensory organ by translating inaccessible information into another sensory modality. However, many substitution systems are not well accepted by subjects. To explore the effect of sensory substitution
    Jiachao Wang et al.
    Behavioural brain research, 372, 112037-112037 (2019-06-17)
    Our internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed
    Benjamin M Basile et al.
    PLoS biology, 18(6), e3000677-e3000677 (2020-06-13)
    A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code
    L T Lopes et al.
    Acta physiologica (Oxford, England), 211(3), 528-537 (2014-03-13)
    Although periaqueductal grey matter activation is known to elicit respiratory and cardiovascular responses, the role of this midbrain area in the compensatory responses to hypoxia is still unknown. To test the participation of the periaqueductal grey matter in cardiorespiratory and
    Intrahippocampal administration of ibotenic acid induced cholinergic dysfunction via NR2A/NR2B expression: Implications of resveratrol against Alzheimer disease pathophysiology
    Karthick C, et al.
    Frontiers in Molecular Neuroscience, 9, 28-28 (2016)
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