I2765
鹅膏氨酸
~95% (TLC), solid, neurotoxin
别名:
α-氨基-3-羟基-5-异噁唑乙酸
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关于此项目
经验公式（希尔记法）:
C5H6N2O4
化学文摘社编号:
分子量:
158.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
鹅膏氨酸, ~95%, solid
InChI
1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
SMILES string
NC(C(O)=O)C1=CC(=O)NO1
InChI key
IRJCBFDCFXCWGO-UHFFFAOYSA-N
assay
~95%
form
solid
color
white
solubility
H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL
Quality Level
Gene Information
rat ... Grm1(24414), Grm2(24415)
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Application
鹅膏蕈氨酸作为神经毒素用于大鼠。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术，以研究逆转增强剂诱导的发声变化。
Biochem/physiol Actions
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。
鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体，破坏丘脑网状核（NRT）。它能诱导大量钙离子流入，导致神经元损伤。由于其具有兴奋性毒性功能，鹅膏蕈氨酸用于诱导产生神经退行性变。
Disclaimer
吸湿
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Megan E Fox et al.
ACS chemical neuroscience, 7(12), 1681-1689 (2016-09-13)
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Angela M Kaindl et al.
Annals of neurology, 72(4), 536-549 (2012-10-31)
Activated microglia play a central role in the inflammatory and excitotoxic component of various acute and chronic neurological disorders. However, the mechanisms leading to their activation in the latter context are poorly understood, particularly the involvement of N-methyl-D-aspartate receptors (NMDARs)
The median raphe nucleus lesion attenuates amnesic effects of ketamine on short-term memory in rats
Babar E, et al.
Journal of Islamic Academy of Sciences, 7(4), 241-246 (1994)
Effects of bilateral microinjections of ibotenic acid in the thalamic reticular nucleus on delta oscillations and sleep in freely-moving rats
Marini G, et al.
Journal of Sleep Research, 9(4), 359-366 (2000)
Loïc J Chareyron et al.
Brain structure & function, 222(9), 3899-3914 (2017-05-11)
Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult
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