一般描述
IgM抗体在血清中以五聚体的形式存在，为响应抗原而产生。
应用
山羊抗人IgM（μ链特异性）抗体可用于酶联免疫吸附测定（ELISA）。
生化/生理作用
免疫球蛋白M（IgM）抗体是针对抗原的反应而产生的主要抗体。它们以低亲和力结合，但是对多种抗原表现出广泛的特异性。IgM占成人免疫球蛋白的15％。由于多种原因，IgM对于胎儿和新生儿的宿主防御很重要。IgM分子高效地激活补体经典途径。其五聚体结构有助于实现与多价配体的结合。IgM在清除血清中的入侵微生物方面具有重要作用。
外形
溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液（pH 7.4）
免责声明
除非我们的目录或随附于产品的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
J Ollila et al.
Genes and immunity, 4(5), 343-350 (2003-07-09)
The development of adaptive immunity and responses to foreign molecules and organisms relies on the highly regulated production of hundreds of proteins. B-cell maturation, from committed progenitors to terminally differentiated plasma cells, is a multistep process that requires the ordered
Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
German EL, et al.
Pneumonia (Nathan Qld.), 10(1), 5-5 (2018)
Esther L German et al.
Pneumonia (Nathan Qld.), 10, 5-5 (2018-07-12)
The incidence of community-acquired pneumonia and lower respiratory tract infection rises considerably in later life. Immunoglobulin M (IgM) antibody levels to pneumococcal capsular polysaccharide are known to decrease with age; however, whether levels of IgM antibody to pneumococcal proteins are
Fredy Brice Nemg Simo et al.
Intervirology, 61(6), 265-271 (2019-05-03)
On May 2017, a case of dengue serotype 1 was detected and confirmed through routine surveillance in a traveler returning from Kribi, a seaside town of Southern Cameroon. This study aimed at confirming the circulation of dengue virus (DENV) in
Yang Li et al.
Cell reports, 34(13), 108915-108915 (2021-03-25)
To fully decipher the immunogenicity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a systematic way. We generate a linear epitope landscape of the Spike protein
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