I1782
Inosine Monophosphate Dehydrogenase Type II human
recombinant, expressed in E. coli
别名:
IMP:NAD oxidoreductase, IMPDH II
recombinant
expressed in E. coli
form
solution
specific activity
≥0.05 units/mg protein
mol wt
~55 kDa
packaging
vial of ≥0.002 unit
UniProt accession no.
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... IMPDH2(3615)
General description
Inosine Monophosphate Dehydrogenase Type II (IMPDH2) is a ubiquitously expressed dominant isoform during developmental stages. IMPDH2 gene is mapped to human chromosome 3p21.31.
Application
Inosine Monophosphate Dehydrogenase Type II human has been used to test the inhibitory effect on vacor adenine dinucleotide (VAD) on its dehydrogenase activity.
Biochem/physiol Actions
Inosine Monophosphate Dehydrogenase Type II (IMPDH2) binds to adenosine triphosphate (ATP) and guanosine triphosphate (GTP). It catalyzes the formation of xanthosine monophosphate from inosine monophosphate in the presence of nicotinamide adenine dinucleotide (NAD). IMPDH2 elevated levels in tumors are correlated to its rate-limiting activity in guanosine monophosphate (GMP) synthesis. High levels of IMPDH2 is implicated in glioblastoma (GBM). It is regarded as a potential therapeutic target against tumors, antiviral, and immunosuppression-related pathologies.
Type II is the predominant IMPDH isoform and is specifically linked to a wide range of cancers and lymphocyte proliferation.
Physical form
Solution in 20 mM Tris-HCl, pH 8.0, containing 0.5 mM EDTA and 1 mM DTT.
Other Notes
One unit will produce 1.0 μ mole of XMP from IMP with corresponding reduction of β-NAD per minute at pH 8.0 at 25 °C.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Lizbeth Hedstrom
Critical reviews in biochemistry and molecular biology, 47(3), 250-263 (2012-02-16)
The inosine monophosphate dehydrogenase (IMPDH)/guanosine monophosphate reductase (GMPR) family of (β/α)(8) enzymes presents an excellent opportunity to investigate how subtle changes in enzyme structure change reaction specificity. IMPDH and GMPR bind the same ligands with similar affinities and share a
Rebecca R Midtkandal et al.
Bioorganic & medicinal chemistry letters, 22(16), 5204-5207 (2012-07-17)
2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a
Bertrand Daignan-Fornier et al.
Cells, 8(1) (2019-01-20)
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is
Travis J Loya et al.
Nucleic acids research, 40(15), 7476-7491 (2012-05-09)
The yeast IMD2 gene encodes an enzyme involved in GTP synthesis. Its expression is controlled by guanine nucleotides through a set of alternate start sites and an intervening transcriptional terminator. In the off state, transcription results in a short non-coding
Sivapriya Kirubakaran et al.
Bioorganic & medicinal chemistry letters, 22(5), 1985-1988 (2012-02-09)
Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5'-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents
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