推荐产品
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
whole antiserum
抗体产品类型
secondary antibodies
克隆
polyclonal
包含
15 mM sodium azide
技术
immunoelectrophoresis: suitable
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
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一般描述
Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. IgG is usually found as a monomer. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin M (IgM ) is a high molecular weight protein that has five or six subunits. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.
特异性
The antiserum is determined to be immunospecific for human IgG, IgA and IgM. Reactivity is also observed against light chains.
应用
Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in goat has been used in immunoassays/sandwich immunoassay and enzyme-linked immunosorbent assay (ELISA).
生化/生理作用
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin G (IgG) participates in hypersensitivity type II and type III. Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions.
外形
The antibody is supplied as a liquid containing 0.1% sodium azide.
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells
Jager V, et al.
BMC biotechnology, 13(1), 52-52 (2013)
Volker Jäger et al.
BMC biotechnology, 13, 52-52 (2013-06-28)
The demand of monospecific high affinity binding reagents, particularly monoclonal antibodies, has been steadily increasing over the last years. Enhanced throughput of antibody generation has been addressed by optimizing in vitro selection using phage display which moved the major bottleneck
Torque-actuated valves for microfluidics
Weibel DB, et al.
Analytical Chemistry, 77(15), 4726-4733 (2005)
Hannah L Itell et al.
Microbiology spectrum, 9(2), e0129821-e0129821 (2021-10-21)
Wide-scale assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies is critical to understanding population seroprevalence, correlates of protection, and the longevity of vaccine-elicited responses. Most SARS-CoV-2 studies characterize antibody responses in plasma/sera. While reliable and broadly used, these
Jan Holmgren et al.
Nature medicine, 11(4 Suppl), S45-S53 (2005-04-07)
There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of
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