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一般描述
IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces
Anti-Human IgA (α-chain specific) antibody specifically recognizes human IgA.
Anti-Human IgA (α-chain specific) antibody specifically recognizes human IgA.
Immunoglobulin A (IgA) is the primary antibody involved in mucosal immunity. It is identified by the presence of α-type heavy chains. IgA which is composed of two subclasses IgA1 and IgA2 can exist in a dimeric secretory form found in mucous secretions.
Specificity for the α-chain of human IgA is determined by Ouchterlony Double Diffusion (ODD). The antibody preparation is specific for human IgA when tested against purified human IgA, IgG, IgM, Bence Jones kappa and Bence Jones λ myeloma proteins.
免疫原
Purified human IgA
应用
Anti-Human IgA (α-chain specific) antibody is suitable for Ouchterlony double diffusion. The antibody was used for IgA quantification by ELISA in various studies. Antibody dilution of 1:4000 was used for passive hemagglutination inhibition assay.
Goat polyclonal anti-human IgA (α-chain specific) antibody may be used to locate and identify the α-chain of human IgA by immunocytochemical and immunohistochemical (IHC) techniques.
外形
Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Mikael Sonesson et al.
European journal of oral sciences, 119(1), 15-20 (2011-01-20)
According to previous studies, minor glands produce about 35% of the total salivary immunoglobulin A (salivary IgA). The age-dependent increase in whole-saliva salivary IgA concentrations has been studied extensively, but we found no published reports comparing the minor-gland saliva concentrations
Leif K Nielsen et al.
Transfusion, 48(9), 1892-1897 (2008-06-03)
To avoid anaphylactic reactions, immunoglobulin (Ig)A-deficient patients with anti-IgA should be transfused with IgA-deficient blood components. There is a need for fast and robust assays for demonstration of IgA deficiency and for detection of anti-IgA. Recombinant human IgA1 and IgA2
Dan Ericson et al.
Pathogens and disease, 68(3), 82-87 (2013-06-06)
We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti-mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice
Hannah Andersson et al.
International journal of microbiology, 2016, 8469018-8469018 (2017-01-20)
Objective. To clarify the effect of Lactobacillus plantarum 299v on the salivary cortisol and salivary IgA levels in young adults under examination stress. Design. Forty-one students with an upcoming academic exam were included in a randomized double-blind, placebo-controlled study. The
Mr Md Saiful Islam Roney et al.
Human pathology, 128, 1-10 (2022-06-25)
The presence of IgA- and IgM-specific autoantibody (AAb) isotypes and their relationship to p53 tissue expression patterns are not well understood. This study aims to investigate the clinical utility of the anti-p53 AAb isotypes and tissue positivity in colorectal cancer
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