跳转至内容
Merck
CN
所有图片(1)

主要文件

安全信息

I0516

Sigma-Aldrich

胰岛素 溶液 来源于牛胰腺

10 mg/mL insulin in 25  mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

别名:

Bovine insulin, Cell culture grade insulin

登录查看公司和协议定价
所有图片(1)

About This Item

CAS号:
11070-73-8
MDL编号:
MFCD00131380
UNSPSC代码:
12352209
NACRES:
NA.77
表单:
solution

无菌性

sterile-filtered

质量水平

400

产品线

BioReagent

表单

solution

浓度

10 mg/mL insulin in 25  mM HEPES, pH 8.2

技术

cell culture | mammalian: suitable
single cell analysis: suitable

杂质

endotoxin, tested

pH值（酸碱度）

7.9-8.5

UniProt登记号

P01317

运输

ambient

储存温度

2-8°C

SMILES字符串

SC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@H](CC)C)C(C)C)CCC(=O)O)CCC(=O)N)CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[

InChI

1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1

InChI key

XYPANFGXFLOTDK-CJLNJPJHSA-N

基因信息

bovine ... INS(280829)
cow ... INS(280829)

相关类别

应用

牛胰腺胰岛素溶液已用于：
  • 研究外源胰岛素对发育期肉牛血浆葡萄糖、胰岛素、胰岛素样生长因子 I（IGF-I）和孕酮（P4）浓度的影响
  • 利用原代人滋养层细胞和胎盘绒毛外植体研究妊娠并发症期间胎盘的胰岛素反应性
  • 研究胰岛素受体信号通路对新生小鼠海马神经元树突棘密度的影响

生化/生理作用

胰岛素是一种重要的降糖激素，它的不足会导致 2 型糖尿病患者出现高血糖。
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。

外形

2-8 °C保存

未找到合适的产品？  

试试我们的产品选型工具.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

法规信息

新产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000263011
0000263011
SLCN8817
SLCJ7615
SLCJ8080

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. What is the comparison between International Units (IU) and USP units for insulin?

    The international unit (IU) of insulin is based on the International Standard Preparation of Bioassay (1958). The standard preparation is a mixture of 52% bovine and 48% porcine insulin, containing 24 units/mg. Reference: Martindale: The Extra Pharmacopoeia, 29th ed., p. 392. High purity bovine pancreatic insulin typically assays at approximately 27 USP units per mg. So the IU and USP unit are not identical, but they are approximately 1:1.

  3. What is the amino acid sequence for insulin?

    The sequence and structure of insulin can be found on the product information sheet (under Documents, above).

  4. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  5. How many units/mg am I getting in Product I0516, Insulin solution?

    This solution is made using insulin Product No. I5500.  The potency specification for the I5500 is not less than 27 USP units/mg.  However, we do not test for potency of the final product of this solution.  It is possible some activity is lost during the manufacturing process.

  6. What is the molarity of Product I0516, Insulin solution?

    Product No. I0516 is a 10 mg/mL solution of bovine insulin (MW 5733.5). The molarity is 1.7 μmol/mL or 1.7 mM.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Wafa B'chir et al.
Endocrinology, 159(5), 2153-2164 (2018-04-11)
Given the increasing prevalence of obesity and the metabolic syndrome, identification of intrinsic molecular programs responsible for ensuring fuel homeostasis and preventing metabolic disease is needed. We investigated whether the orphan nuclear receptor estrogen-related receptor α (ERRα), a major regulator
M M Vick et al.
Journal of animal science, 85(5), 1144-1155 (2007-02-01)
Recent studies associate obesity and insulin resistance in horses with development of abnormal reproductive function and debilitating laminitis. The factors contributing to insulin resistance in obese horses are unknown. However, human studies provide evidence that elevated inflammatory cytokines such as
Ana Mato-Berciano et al.
Oncotarget, 8(14), 22700-22715 (2017-02-12)
Notch signaling pathway is an embryonic program that becomes reactivated in pancreatic cancer and contributes to cancer stem cell (CSC) maintenance. We explored the concept of oncolytic adenoviral activity in response to Notch activation signaling, in the context of a
Varsha Prakash et al.
Nature communications, 10(1), 2110-2110 (2019-05-10)
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest.
Kye Won Park et al.
Molecular endocrinology (Baltimore, Md.), 22(9), 2038-2048 (2008-06-20)
We previously identified the small molecule harmine as a regulator of peroxisome proliferator activated-receptor gamma (PPARgamma) and adipocyte differentiation. In an effort to identify signaling pathways mediating harmine's effects, we performed transcriptional profiling of 3T3-F442A preadipocytes. Inhibitor of DNA biding
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门