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质量水平
检测方案
≥98% (HPLC)
形式
solid
分子量
277.28
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
room temp
SMILES字符串
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4ccccc34
InChI
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
InChI key
HBDSHCUSXQATPO-BGBJRWHRSA-N
应用
靛红-3′-肟已被用于抑制人单核细胞系THP-1中的糖原合酶激酶3。
生化/生理作用
靛红-3′-肟在Jurkat T细胞中可介导凋亡，并具有抗肿瘤功能。 靛红-3′-肟可抑制Y框结合蛋白1（YB1）的易位，有助于抗癌功能。 靛红-3′-肟可降低人神经母细胞瘤中雌激素相关受体γ (ERRγ)和过氧化物酶体增殖物激活的受体-γ 共激活因子-1α (PGC1α)的表达，从而导致细胞周期停滞和线粒体功能障碍。
靛红-3′-肟是一种细胞周期蛋白依赖性激酶抑制剂，可通过与ATP竞争结合催化亚基而发挥功能。其具有抗增殖活性，可导致许多细胞系中的G2/M停滞和Jurkat细胞中的G1/S停滞。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Semi-synthesis of indirubin-3′-oxime from Strobilanthes cusia leaves, its acute and sub-chronic toxicity, in vitro and in vivo antitumor activity in Lewis lung carcinoma bearing mice.
Cuong NM, et al.
Journal of Pharmacognosy and Phytochemistry, 5(4), 205-205 (2016)
Dynamic modulation of innate immune response by varying dosages of LPS in human monocytic cells.
Morris M, et al.
The Journal of Biological Chemistry, 289(31), 21584-21590 (2014)
Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells.
Liao XM and Leung KN
Oncology Reports, 29(1), 371-379 (2013)
Mechanism responsible for inhibitory effect of indirubin 3?-oxime on anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells.
Tanaka T, et al.
Experimental Cell Research, 370(2), 454-460 (2018)
Ming-Yang Lee et al.
European journal of pharmacology, 839, 57-65 (2018-09-30)
Cholangiocarcinoma (CCA) is one of the most serious of all cancers and a major public health problem. CCA is an extremely invasive cancer, and the survival rate for CCA patients is only 24 months after diagnosis. Although surgery and chemotherapy
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