Anti-VRK1 antibody produced in rabbit

Vaccinia-related kinase 1 (VRK1) is a nucleosomal kinase belonging to a group of serine/threonine kinases which are associated with breast carcinomas. The gene encoding VRK1 is located on human chromosome 14.

Serine/threonine-protein kinase VRK1 recombinant protein epitope signature tag (PrEST)

Anti-VRK1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Vaccinia-related kinase 1 (VRK1) phosphorylates many transcription factors like tumor suppressor p53 and c-Jun (a kinase). It controls cell-cycle progression wherein it is required for exit from G0 phase and entry into G1 phase. VRK1 interacts with proteins like histones of the chromatin network and is essential for chromatin condensation. It has been shown to phosphorylate histone H3. VRK1 plays an important role in response to DNA damage by UV-light and radiations.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST70405

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.