产品名称
Anti-Huntingtin (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~110 kDa
species reactivity
mouse, human, rat
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using a HEK-293T cell lysate expressing a N-terminal fragment of human huntingtin
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTT(3064)
mouse ... Htt(15194)
rat ... Htt(29424)
Application
Anti-Huntingtin (N-terminal) antibody has been used:
- in magnetic bead-assisted immunopurification
- in western blotting
- in immunofluorescent staining
- in immunoblotting
Biochem/physiol Actions
Huntingtin (Htt) is essential for embryonic development and neurogenesis. Htt associates with various cell organelles like the nucleus, endoplasmic reticulum and Golgi complex. It is also found in neurites and synapses where it associates with vesicular structures and microtubules, suggesting that it may play a role in intracellular vesicular trafficking, calcium homeostasis, neuronal survival, morphogenesis and transcriptional regulation. Aberrant expansion of glutamine repeats (polyQ) in the N-terminal region of huntingtin (htt) causes Huntington′s disease (HD) which is an autosomal dominant neurodegenerative disorder.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-Huntingtin (N-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human huntingtin, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Normal huntingtin function: an alternative approach to Huntington's disease
Cattaneo E, et al.
Nature Reviews. Neuroscience, 6(12), 919-919 (2005)
Huntingtin-protein interactions and the pathogenesis of Huntington's disease
Li SH and Li XJ
Trends in Genetics, 20(3), 146-154 (2004)
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation
Morozova O A, et al.
Febs Letters, 589(15), 1897-1903 (2015)
Luisa Massai et al.
BMC biochemistry, 14, 34-34 (2013-11-28)
Huntington's disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to
A phenotypic screening assay for modulators of Huntingtin-induced transcriptional dysregulation
Lazzeroni G, et al.
Journal of Biomolecular Screening, 18(9), 984-996 (2013)
相关内容
Instructions
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