形式
solid
质量水平
颜色
white
溶解性
H2O: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl[H].Cl[H].CNCCc1c[nH]cn1
InChI
1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
InChI key
AYUQICXJAMPXPF-UHFFFAOYSA-N
生化/生理作用
Nα-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis.
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
质量
The product is pure based on elemental analysis results, NMR and MS spectra.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
N alpha methyl histamine versus propranolol in migraine prophylaxis
Millan GRO, et al.
The Canadian Journal of Neurological Sciences, 41(2), 233-238 (2014)
Noriko Hino et al.
The Journal of pharmacology and experimental therapeutics, 375(2), 276-285 (2020-08-31)
Histamine H3 receptor antagonists/inverse agonists are known to enhance the activity of histaminergic neurons in the brain, thereby promoting arousal and cognition. Here, we report the in vitro and in vivo pharmacological profiles for a newly synthesized histamine H3 receptor
Effects of N-alpha-methyl-histamine on human H2 receptors expressed in CHO cells
Saitoh T, et al.
Gut, 50(6), 786-789 (2002)
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