推荐产品
质量水平
检测方案
≥98%
形式
ethanol solution
运输
wet ice
储存温度
−20°C
SMILES字符串
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)Nc1ccc(O)cc1
InChI
1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15-
InChI key
IJBZOOZRAXHERC-DOFZRALJSA-N
基因信息
human ... CNR1(1268) , CNR2(1269)
mouse ... Cnr2(12802)
rat ... Cnr1(25248) , Faah(29347) , Trpv1(83810)
应用
Potentiates the activity of endogenous anandamide by blocking its re-uptake into presynaptic membranes. AM404 selectively inhibits the carrier-mediated transport of anandamide without affecting anandamide hydrolysis.
其他说明
To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
55.4 °F
闪点(°C)
13 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Maria Scherma et al.
British journal of pharmacology, 165(8), 2539-2548 (2011-05-12)
The fatty acid amide hydrolase inhibitor URB597 can reverse the abuse-related behavioural and neurochemical effects of nicotine in rats. Fatty acid amide hydrolase inhibitors block the degradation (and thereby magnify and prolong the actions) of the endocannabinoid anandamide (AEA), and
A Giuffrida et al.
European journal of pharmacology, 408(2), 161-168 (2000-11-18)
The biological actions of the endogenous cannabinoid anandamide are terminated by carrier-mediated transport into neurons and astrocytes, followed by enzymatic hydrolysis. Anandamide transport is inhibited by the compound N-(4-hydroxyphenyl)arachidonylamide (AM404). AM404 potentiates several responses elicited by administration of exogenous anandamide
M Beltramo et al.
Science (New York, N.Y.), 277(5329), 1094-1097 (1997-08-22)
Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into cells or by enzymatic hydrolysis. The compound N-(4-hydroxyphenyl)arachidonylamide (AM404) was
F M Leweke et al.
Translational psychiatry, 2, e94-e94 (2012-07-27)
Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevation of anandamide levels in cerebrospinal fluid inversely correlated to psychotic symptoms. Furthermore, enhanced
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