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Merck
CN

H1007

Sigma-Aldrich

L-高精氨酸 盐酸盐

≥98% (TLC)

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别名:
S)-2-氨基-6-胍基己酸 盐酸盐
线性分子式:
H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl
CAS号:
分子量:
224.69
Beilstein:
4016621
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

质量水平

检测方案

≥98% (TLC)

形式

powder

颜色

white to off-white

mp

213-215 °C (lit.)

溶解性

H2O: soluble

应用

peptide synthesis

SMILES字符串

Cl[H].N[C@@H](CCCCNC(N)=N)C(O)=O

InChI

1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1

InChI key

YMKBVNVCKUYUDM-JEDNCBNOSA-N

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应用

L-高精氨酸可用于产生非天然蛋白质,用于翻译后蛋白质修饰的研究。精氨酸残基常位于蛋白质和酶的活性中心。将这些精氨酸替换为高精氨酸有助于阐明蛋白质的功能和结构要求。L-高精氨酸用于研究细胞通过一氧化氮合酶 (s) 产生一氧化氮的机制。L-高精氨酸用作选择性哺乳动物碱性磷酸酶同工酶抑制剂。高精氨酸取代精氨酸或赖氨酸使蛋白质对胰蛋白酶水解产生抗性。
高精氨酸取代精氨酸或赖氨酸使蛋白质对胰蛋白酶的蛋白水解具有抗性。精氨酸残基常位于蛋白质和酶的活性中心。将这些精氨酸替换为高精氨酸有助于阐明蛋白质的功能和结构要求。

生化/生理作用

高精氨酸是组织非特异性碱性磷酸酶 (TNALP) 的抑制剂。也是通过钠非依赖性高亲和力 y + 转运体进行精氨酸细胞转运的抑制剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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