推荐产品
生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-22760
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... STAT6(6778)
免疫原
Immunogen Sequence: GI # 23397678, sequence 61-275
Recombinant signal transducer and activator of transcription 6
应用
Anti-STAT6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
STAT6 is a human gene and is a member of the STAT family of transcription factors. It is mapped to human chromosome band 12q13. STAT6 has the same functional domain for both receptor coupling and dimerization. It is highly expressed in comparison with the other STAT proteins. STAT-6 silencing results in the reduction of HeLa cell programmed death and the expression of several important key factors related to programmed cell death. It is a highly sensitive and specific marker of solitary fibrous tumor (SFT). It can also be helpful in distinguishing tumor type from histologic mimics.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Akihiko Yoshida et al.
The American journal of surgical pathology, 38(4), 552-559 (2014-03-15)
Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm. Although histologic characteristics and frequent CD34 expression allow for an accurate diagnosis in the majority of SFT cases, a wide histologic spectrum and an occasional unexpected immunophenotype may pose diagnostic challenges.
Zhibin Li et al.
Biomaterials, 35(18), 5016-5027 (2014-03-29)
Based on the fact that the transcription of STAT-1 plus its Serine 727 and Tyrosine 701 phosphorylation is not the pre-requisite for the cell death signal transduction in the IFN-γ signaling pathway induced by co-immobilized IFN-γ/TNF-α, we investigate both in
Leona A Doyle et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(3), 390-395 (2013-09-14)
Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like vessels. Some tumors show hypercellularity, nuclear atypia, and significant mitotic activity; the latter feature in particular often portends an
Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization.
J P Leek et al.
Cytogenetics and cell genetics, 79(3-4), 208-209 (1997-01-01)
J Hou et al.
Science (New York, N.Y.), 265(5179), 1701-1706 (1994-09-16)
Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance
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