生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, mouse, rat
制造商/商品名称
Genway 15-288-21286A
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EWSR1(2130)
免疫原
Immunogen Sequence: GI # 4885225, sequence 380-448
Recombinant ewing sarcoma breakpoint region 1 isoform EWS
应用
Anti-EWSR1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
RNA-binding protein EWS is a protein encoded by the EWSR1 gene in humans and is located on human chromosome 22. It is involved in a wide variety of sarcomas as well as some non-mesenchymal tumours. EWSR1 is a ′promiscuous′ gene that can fuse with many different partner genes, resulting in identical tumours. It can partner with the same genes in morphologically and behaviourally different neoplasms. EWSR1 rearrangement is also associated with a variety of salivary gland lesions including classic myoepitheliomas and hyalinizing clear cell carcinomas (HCCCs). It also acts as a novel modulator of cis-acting replication element (CRE) function in hepatitis C virus (HCV) replication.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Cyril Fisher
Histopathology, 64(1), 134-150 (2013-12-11)
Many soft tissue sarcomas have chromosomal translocations with resultant formation of new fusion genes. Among the genes that can be rearranged, the EWSR1 gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas
O Delattre et al.
Nature, 359(6391), 162-165 (1992-09-10)
Ewing's sarcoma and related subtypes of primitive neuroectodermal tumours share a recurrent and specific t(11;22) (q24;q12) chromosome translocation, the breakpoints of which have recently been cloned. Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions
Todd E Oakland et al.
Journal of virology, 87(12), 6625-6634 (2013-04-05)
The hepatitis C virus (HCV) genome contains numerous RNA elements that are required for its replication. Most of the identified RNA structures are located within the 5' and 3' untranslated regions (UTRs). One prominent RNA structure, termed the cis-acting replication
Akeesha A Shah et al.
The American journal of surgical pathology, 37(4), 571-578 (2013-02-22)
The Ewing sarcoma breakpoint region 1 (EWSR1) is translocated in many sarcomas. Recently, its rearrangement has been described in salivary gland hyalinizing clear cell carcinomas (HCCCs) and in a subset of soft tissue myoepitheliomas. This study examines the presence of
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