生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, human, mouse
制造商/商品名称
Genway 15-288-21258
技术
western blot: suitable
NCBI登记号
免疫原
Immunogen Sequence: GI # 4826930, sequence 1-110
Recombinant peroxisome proliferative activated receptor gamma, isoform 1
应用
Anti-PPARγ antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
Peroxisome proliferator-activated receptor γ(PPAR-γ or PPARG) is a type II nuclear receptor encoded by the PPARG gene in humans. PPARs are ligand-activated transcription factors of the nuclear hormone receptor superfamily. PPARγ is expressed as two isoforms, PPARγ2 and PPARγ1. PPARγ2 is expressed at high levels in the adipose tissues, whereas PPARγ1 has a broader expression pattern. PPARγ2 in skeletal muscle can promote conversion of subcutaneous fat to brown fat formation leading to increased energy metabolisms and combating obesity. PPARγ mRNA is expressed in humans in spleen, bone marrow, liver, testis, skeletal muscle and brain, in addition to fat.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Jaakko L O Pohjoismäki et al.
Nucleic acids research, 40(14), 6595-6607 (2012-04-18)
Cardiomyocyte development in mammals is characterized by a transition from hyperplastic to hypertrophic growth soon after birth. The rise of cardiomyocyte cell mass in postnatal life goes along with a proportionally bigger increase in the mitochondrial mass in response to
Ying Zhou et al.
Biochemical and biophysical research communications, 446(4), 959-964 (2014-03-20)
Brown adipose tissue (BAT) is specialized to dissipate energy as heat, therefore reducing fat deposition and counteracting obesity. Brown adipocytes arise from myoblastic progenitors during embryonic development by the action of transcription regulator PRDM16 binding to PPARγ, which promotes BAT-like
Liliane Michalik et al.
Pharmacological reviews, 58(4), 726-741 (2006-11-30)
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand- and cofactor-binding domain.
Juan Pablo Lezana et al.
Developmental neurobiology, 76(6), 688-701 (2015-10-09)
PPARγ is a ligand-activated nuclear receptor best known for its involvement in adipogenesis and glucose homeostasis. PPARγ activity has also been associated with neuroprotection in different neurological disorders, but the mechanisms involved in PPARγ effects in the nervous system are
A Elbrecht et al.
Biochemical and biophysical research communications, 224(2), 431-437 (1996-07-16)
We describe the molecular cloning and expression of cDNAs encoding human PPAR gamma 1 and PPAR gamma 2. Our sequences are distinct from the published sequence at 3 positions, resulting in nonconservative amino acid substitutions. In humans, PPAR gamma mRNA
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